What Can a Neuropeptide Cream Do for Me?

The skin is the most vulnerable organ. It is bombarded daily with secondhand smoke, smog, dirt particles, germs, sun rays, and other harmful substances that can diminish its luminosity. In fact, there are more than 75,000 toxic chemicals classified by the EPA as potentially or definitely hazardous to human health. In fact, researchers now believe traces of arsenic can be found in coffee. Imagine how many of these dangerous substances pose a threat to human skin every day.

Diet, exercise, and nutrition are the first steps toward being and looking healthy. To take the next step, it’s important to give vulnerable skin the care it deserves. Modern cosmetic science has identified ingredients that give the outside of the body, especially precious facial skin, advanced care for the damage it receives every day. One of the most exciting ingredients in use today is neuropeptides.

Want to learn more?

What are neuropeptides?

If you’re familiar with a little high school biology, then you likely have heard of neuropeptides; however, if this is the case, you’re likely wondering how neuropeptides relate to the skin. After all, the prefix “neuro” signifies neuropeptides are related to neurological (i.e. brain) functions.

However, research has pointed to a link between the brain and the skin, which involves a communication series:

  1. The brain signals the thymus.
  2. The thymus signals the skin.
  3. The skin responds to the brain.

The thymus gland, processor of white blood cells, produces neuropeptides. Neuropeptides serve as the glue holding neurotransmitters, hormones, and enzymes together to keep them working in sync.

Neuropeptides are peptides, compounds made up of two or more bonded amino acids, released by brain cells either as neurotransmitters or as hormones:

  • Neurotransmitters are chemical substances that send nerve impulses across synapses.
  • Hormones affect the functions of receptive organs or tissues when transported to them.

How do neuropeptides help aging or damaged skin?

Without neuropeptides, communication in the brain, let alone throughout the body, would not function properly. However, body chemicals like neuropeptides can exert dual effects. Neuropeptides can produce pro-inflammatory or anti-inflammatory effects. For example, substance P, a type of neuropeptide, is involved in the release of saliva and urine. It also helps widen blood vessels and tighten smooth muscles, like those in the intestines. Yet, substance P can trigger inflammation in the skin, causing wrinkling and acne. Substance P is also linked to chronic conditions such as aging, depression, obesity, alcoholism, and pain.

Neuropeptide Y, on the other hand, has the opposite effect of Substance P. When it is released into the brain, it lessens anxiety and depression while increasing appetite and memory ability. Neuropeptide Y also constricts blood vessels and regulates body temperature, blood pressure, and the release of sex hormones.

As previously mentioned, there is a connection between the brain and the skin, and neuropeptides certainly are important for the brain. What is therapy to the brain is therapy to the skin.

In fact, neuropeptides work in a number of ways against aging or damaged skin:

  1. Revive dull, lifeless skin
  2. Maintain a fresh and rosy appearance

  3. Minimize discoloration
  4. Reduce dark circles under eyes
  5. Decrease fine lines and wrinkles
  6. Protect from free radicals
  7. Decrease sagging
  8. Improve blood circulation and cell metabolism

As we age, our body’s production of neuropeptides begins to dwindle. Neuropeptides work wonders for aging skin that has advanced to a level of deep lines and wrinkles. They are natural and nontoxic, unlike popular and costly Botox treatments, and play an important role in the beauty and appearance of skin.

For a comparison of natural treatments vs. Botox, watch this video:

How can the supply be replenished, or better yet, refueled?

Will a neuropeptide cream help?

Years ago, people trusted in diet and exercise to regain neuropeptide control. But now, thanks to important skin research, we can apply them directly to our skin. Dr Perricone‘s Neuropeptide Facial Conformer combines powerful antioxidant protection with a nourishing moisturizer.

This neuropeptide cream tightens facial contours with the following ingredients:

  • Neuropeptides renew the skin surface, smoothing lines and wrinkles as they tone and firm.
  • DMAE also firms and tones skin while enhancing facial contours and boosting fellow antioxidants.
  • Phospholipids absorb quickly to repair and hydrate damaged, dry skin.

Neuropeptide Firming Moisturizer, does so much more than treat dry skin, it:

  • Firms
  • Lifts
  • Tones
  • Repairs

The moisturizer, containing the same key ingredients as the Facial Conformer, hydrates and tones sagging skin while correcting wrinkles and fine lines. The ingredients interact in a different way, putting an emphasis on the phospholipids which mimic lipids found naturally in skin, allowing for nearly instant absorption.

Dr. Perricone believes there is an immediate radiance added to the skin within minutes after application of his neuropeptide products. He believes it enough to offer special Perricone coupons for the products you order. Firmness increases and skin is hydrated. Even the appearance of tiny veins and capillaries diminishes. But he insists neuropeptide research is still in its infancy with a multitude of uses just waiting to be unlocked.


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22 Comments • Please comment below


  1. I am very determined to find something that works!

  2. DR. Perricone
    I just finished your book, “The Perricone Promise” and found it very informative. I even bought several copies to give to friends and family. I am starting your diet and supplement program today. I have to tell you that I am tired of spending money on products that promise the world and deliver litte if anything. My 50th birthday is coming up Aug 20 and honestly I am a little freaked out about it. I have always thought I looked good for my age but lately I don’t think so as much. People always have told me that I look young for my age but not so much anymore. I have some wrinkles around the eyes and jowling and marionette lines and age spots that I would love to get rid of. I have been seriously considering botox and fillers as a birthday present to myself for my upcoming 50th birthday next month. I have watched you on PBS and wondered if your products really worked. As a single divorced mom I feel like I should not be wasting money on expensive products that do not work. It would be a priviledge and I would be grateful to be picked as a tester. Please pick me.

  3. I would love to be a tester. I am starting to think that I am losing firmness around my eyes, cheeks and jaw line.

  4. I am using the neuropeptid cream I took a chance whent they broke it into payments on QVC. My face is plump and smooth again around my nasal area. My skin is so smooth and supple. I have spent lots of money and tried hundred products but this one really makes a big difference fast.

  5. About 20 years ago, I became very proactive with what I eat AND put on my skin. I study ingredients diligently and stay away from mainstream chemical laden skin care products. Until now I have used all natural skin care based upon aloe vera and argan oil, I am 49, but am mistaken for 30 many times over. I am trying the neuropeptide line, because I did not see any parabens in the ingredients and most of them are not harmful to the body. I am putting Dr. P. to the test to see if he can make my skin look even younger and to decide if the products are worth top dollar. I always find that I get what I pay for, but not so true in the skin care world, some companies are charging high prices for harmful products. As long as I don’t find out that Perricone tests on animals, I may stick with the neuropeptide line, have tolerated it well so far, I’m just waiting to be mistake for 29!! Perhaps I should be considered for a Perricone tester!

  6. I sampled some of the conforming cream at a local store and it did seem to have immediate effects. Would be interested in trying some samples over a period of time before investing in the product.

  7. I’ve been using the neuropeptide facial contour and the face activiator for about 3 weeks now and my skin is firmer, I did order the wrinkles serum to help with the wrinkles around my mouth and around my eyes, can’t wait to start on it.


  9. [...] What Can a Neuropeptide Cream Do for Me? [...]

  10. [...] neuropeptide cream do you want to [...]

  11. I have been using NFM for about 3 weeks now, and have noticed a significant improvement in the condition of my skin. I would love to try more Perricone products – I have many allergies, so the sampling program has been fantastic to try different items before buying the full size products.

  12. [...] neuropeptide cream has the ability to [...]

  13. [...] an extensive line of skin care products designed for a more youthful look. One of these products, Neuropeptide Eye Contour, is formulated specifically for the eye area. This rich cream can be applied gently to [...]

  14. Almost reaching thirty my skin is just now really noticable as losing its firmness, I see my face getting thinner and my cheeks disappearing. :( I would be overjoyed at seeing firming results to my newly noticable deteriorating skin.

  15. Just received my sample of Neuropeptide Firming Moisturizer today! Can’t wait to see how it will improve my skin!! I would love to become a Perricone tester. Thanks Dr. Perricone for all your research and great information!!!!!

  16. I have never tried this product but it sounds fabulous. I’m a little skeptical as to how a neuropeptide cream can reduce dark undereye circles, but I’m definitely willing to try it.

  17. Neuropeptide cream sound the like cure all of every complaint we could have about our skin. While Neuropeptides are small protein-like molecules used by neurons rather than direct communicators I doubt that one is actually applying these molecules to their skin. However my experience with Dr. Perricone’s product’s to date is that they make my skin feel very hydrated and smooth. One will have to see over time what these so called Neuropeptides can do.

  18. Have used some of Dr. Perricone products and love everyone that I have tried so far. I would like to try cold plasma or anyother of his new products. I have problems around the eyes with dark circles and puffness.

  19. Would love to try product. Have very sensitive/dry skin that reacts to many anti-aging products on the market. Would this product work well with my skin type?

  20. I would love to try this product. I’ve heard good things. I want to have a flawless complexion.

  21. I just started using this product. I can see a difference right away. I am impressed and this will motivate me to try the other products. thank you.

  22. I’d love Neuropeptide Cream to help me achieve a complexion that looks as if I have a FLAWLESS FACE!!!Getting old can be a great thing if you have great skin treatments!!!