Treat Under Eye Circles with Neuropeptide Cream

While there is more than one cause for dark, puffy under eye circles, the most common are excess skin pigmentation and free radical damage.

Both skin discoloration and free radical damage result from damage associated with aging and sun exposure, and can combine to make you look tired or sick.

However, certain active ingredients can fight the causes of under eye circles and give your eye area the therapy it needs.

Read on to learn about these ingredients and their relation to the treatment of under eye circles.

Neuropeptides and Under Eye Circles

Neuropeptides are peptide chains that function in the nervous system. Neuropeptides transmit signals and can act as neurotransmitters or neuromodulators.

Because of their ability to transmit and regulate signals in the body, neuropeptides can diminish already existing wrinkles, which become smaller and less noticeable, and prevent new ones from forming.

Neurons, the brain’s broadcasters, use small, protein-like molecules called neuropeptides to communicate with each other. Neuropeptides are signaling molecules that influence brain activity in highly specific ways.

They are involved in particular brain functions such as:

  • Reward
  • Hunger
  • Learning
  • Memory

When used in a skin treatment cream, neuropeptides boost production of collagen and elastin and increase circulation.

Most importantly, a neuropeptide cream can help combat under eye circles through skin surface renewal, which can remove dead skin cells that contribute to under eye circles.

DMAE and Under Eye Circles

Dimethylaminoethanol, also known as DMAE, is an organic compound produced by the body’s metabolic processes.

Found naturally in fish (such as sardines or anchovies), DMAE supplements have been shown to:

  • Increase life span
  • Prevent damage to DNA
  • Aid brain function
  • Improve cardiovascular and immune health
  • Increase energy and mood

DMAE is simpler derivative of a choline molecule. Choline is part of the formation of the neurotransmitter acetylcholine. Acetylcholine is critical to muscle function.

Because DMAE is simpler than choline, it better permeates the blood-brain barrier (i.e. the brain’s protective shield). Therefore, DMAE offers a more direct approach to the creation of acetylcholine in the brain, and therefore improved muscular function.

For the skin, this means improved facial muscle tone and reduction of sagging skin for a more youthful appearance.

Additionally, DMAE functions as an antioxidant that fights free radical damage. Free radicals are unstable molecules that are missing one or more electrons. In an attempt to stabilize themselves, free radicals take electrons from nearby molecules, such as collagen, causing damage to these molecules.

Antioxidants have extra electrons that they give to free radicals, stabilizing them and preventing them from damaging skin cells.

DMAE, with antioxidant properties, provides numerous benefits for the skin, including:

  • Firming and toning skin
  • Enhancing facial contours
  • Strengthening other antioxidant treatments

Because DMAE aids muscle function and fights free radical damage that causes sagging, it is a helpful ingredient for reducing the appearance of sagging under eye circles.

Phospholipids and Under Eye Circles

Phospholipids mimic the skin’s natural lipids, which allow them to be quickly absorbed. Phospholipids can attract water from the air and also hold water where hydration is needed in the skin. Environmental factors such as sun, wind, and pollution can strip natural phospholipid content from the top layer of the skin, resulting in a rough, pitted appearance.

Good sources of phospholipids include berries, wine, olive oil, and most especially, green and black tea.

Moisturizing with products that contain phospholipids does the following:

  • Replaces the skin’s natural protective layer
  • Repairs damaged skin
  • Hydrate and treats dry, fragile, or chapped skin
  • Calms and soothes dry or sensitive skin

Because phospholipids easily absorb into and protect fragile skin, they are helpful for keeping the skin underneath the eyes strong and resistant to sagging and under eye circles.

Pericone MD’s active ingredient-rich Neuropeptide Eye Contour contains neuropeptides, DMAE, and phospholipids to battle the contributors to under eye circles. Specifically, it works to

  • Firm sagging, fragile skin
  • Diminish the appearance of discoloration
  • Reduces puffiness

With twice daily use, eyes will take on a more youthful and healthy looking appearance.

Neuropeptide Eye Contour complements Neuropeptide Facial Conformer and Neuropeptide Firming Moisturize also by Dr. Nicholas Perricone.

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6 Comments • Please comment below


  1. I am allergic to many seafood items (including sardines and anchovies) and I am just wondering if this product is OK to use?

    I am guessing it will be fine as the active ingredient is only a small part of the fish.

    Does anyone with similar circumstances any experience with this product?

  2. I don’t have dark circles as such, but my family has a history of that terrible second layer of lines following their 50′s. I wonder if this would aid in reducing the loose skin and therefore lines that look terrible with someone who is young at heart.

  3. I have had severe dark circles since a teenager, and am desperately seeking a product that will help improve them so that I can easily cover them with makeup!
    Would love to see if this is it!

  4. I’ve tried EVERY cream out there for my dark circles!

    I am at my wits end and would love to try a sample of this treatment before I spend one more dollar!

    Thank you so much!

    Warm regards,

    Ann M. O’Connor

  5. I’ve tried a variety of products to combat dark circles and am still looking for the magic product. I’d definitely love to see if this is it!

  6. Hi, I’ve had ‘dark circle’ issues since I was a teen. The first time I used this product myself and my daughter saw the improvement. After a couple months, my mom from out of town visited. She commented on how my eyes looked better. She didn’t know I was using any product, and she doesn’t generally say anything about my looks. To me, that confirmed that there was a huge difference.