Subclinical Inflammation: Perricone’s Theory of Aging

Free radicals are a central player in the aging process, but subclinical inflammation is also an integral participant, according to Dr. Perricone’s inflammation theory of aging. And although subclinical inflammation is invisible to the naked eye, its effects on skin are not.

Subclinical inflammation is caused by free radical damage. When free radicals attack the cell plasma membrane, arachidonic acid is produced by an enzyme called phospholipase A2, which is triggered when the skin is traumatized. Arachidonic acid becomes oxidized into chemicals that result in inflammation.

Once inflammation occurs, it produces more free radicals, continuing the cycle and accelerating aging in all organ systems, including the skin.

Inflammation is triggered by external factors such as:

  • Cigarette smoke
  • Ultraviolet radiation
  • Air pollution
  • Pro-inflammatory diet
  • Weakened immune system
  • Stress
  • Lack of sleep

Dr. Perricone’s 3-tier philosophy to treat inflammation can help treat and prevent the signs of aging.

Watch the video below for an overview of Perricone’s philosophy and theory of aging:



To sum up the video, Dr. Perricone’s 3-tier philosophy consists of following: an anti-inflammatory diet, ingesting anti-inflammatory supplements, and applying anti-inflammatory topical treatments. Sure, any of these tiers alone can help you achieve results, but the triple threat is the best way to quickly rejuvenate the skin and all organ systems, including the brain. In fact, following an anti-inflammatory diet and taking anti-inflammatory supplements can keep your mood elevated.

To get started on treating inflammation topically, consider incorporating Perricone MD Active Tinted Moisturizer with SPF 15 into your regimen. Perricone’s Active Tinted Moisturizer is formulated with antioxidants alpha lipoic acid and vitamin C ester. It also includes DMAE, which not only enhances the strength of these antioxidants, but acts as an antioxidant because of its ability to protect the cell from free radical damage.


Available in 3 different tints, this moisturizer is great since it does more than just moisturize, add a hint of color, and protect from the UV radiation that causes inflammation. Thanks to its formulation, Active Tinted Moisturizer provides antioxidant protection from free radicals and thus inflammation, while helping to minimize signs of aging such as wrinkles and loss of elasticity. The vitamin C ester also imparts a healthy and radiant glow.

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13 Comments • Please comment below

13 Comments

  1. Would love to become a tester! Anything within reason to halt the adverse effects of aging. . . Thank You!

  2. Sounds GREAT. Please consider me for the trial. I am already taking amazing supplements – NutriShield (see uni-vite.com/nutrishield) which has had a HUGE improvement on my skin and vitality. So if I can add a vitamin enhanced skincare product I should have everything I need – inside and out!

  3. I would love to be a tester!

  4. good information, and I will always follow the next article.
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  5. These sound like such great products! I would really like to test some! I also am looking for a product with Vitamin C! It feels good when you have smooth skin!

  6. My face would love for me to become a tester for you!

  7. very interested in testing out these products. I would love to try a product with vitamin C. It is hard to find them at stores.

  8. I am interested in becoming a tester.

  9. Thank you. I would like to be considered for testing this product. I am over 50 with great skin and few wrinkles. I like a medium tint with a moisturizer as my skin is dry due to winter and aging. I am looking for products that contain vitamin C as I am an occasional smoker and have also recently read that vit. C is excellent for skin care. My current products do not contain vit. C. I have heard such positive fbk regarding Dr. Perricones products and am anxious to get on board with trying them. With Regards, Joan from Atlanta

  10. Thank you. I would like to be considered for testing this product. I am over 50 (54) with great skin and few wrinkles. I like a medium tint with a moisturizer as my skin is dry due to winter and aging. I am looking for products that contain vitamin C as I am an occasional smoker and have also recently read that vit. C is excellent for skin care. My current products do not contain vit. C. I have heard such positive fbk regarding Dr. Perricones products and am anxious to get on board with trying them. With Regards, Joan from Atlanta

  11. Thank you. I would like to be considered for testing this product. I am over 50 (54) with great sking and few wrinkles. I Like a medium tint with a moisturizer as my skin is dry due to winter and aging. I am looking for products that contain vitamin C as I am an occasional smoker and have also recently read that vit. C is excellent for skin care. My current products do not contain vit. C. I have heard such positive fbk regarding Dr. Perricones products and am anxious to get on board with trying them. With Regards, Joan from Atlanta

  12. I would love to become a product tester! I currently use lancome and arbonne products and would love to try something new if it could possibly be better for my skin!!!

  13. I have done product testing in the past & I loved influencing companies. It was great & I’d love to do it again!!!