Perricone MD – Neuropeptide Firming Moisturizer

If your skin is dry and devitalized, Neuropeptides can help stimulate the skin renewal you seek for younger looking skin.

As its name reveals, Neuropeptide Firming Moisturizer is formulated with advanced proprietary Neuropeptide technology for regenerated, lifted, and luminous skin. This moisturizer has other notable anti-aging ingredients to help correct the appearance of deep lines and wrinkles and more.

Tell us why you want Neuropeptide Firming Moisturizer for a chance to win it!

Want to learn more?

Try Perricone for as little at $10.

Key Sciences in Neuropeptide Firming Moisturizer

Neuropeptide Firming Moisturizer is a highly advanced anti-aging cream that delivers rich and corrective nutrients, antioxidants, and emollients to the skin. Formulated with Dr. Perricone’s most powerful patented anti-aging ingredients, Neuropeptide Firming Moisturizer promises to intensely renew, moisturize, and nourish dry, mature skin.

First, intensely potent Neuropeptides activate surface renewal of the dermis, while smoothing lines and wrinkles. Neuropeptides also improves the appearance of sagging or crepey skin, while delivering more toned, supple, and resilient skin.

In addition to Neuropeptides, this firming moisturizer also includes: DMAE, Phospholipids, and Tocotrienols.

DMAE firms, tones, and re-contours skin for immediate plumpness. Anti-inflammatory DMAE enhances the strength of other antioxidant therapies.

Quick-absorbing Phospholipids (Phos E) repair, hydrate, and treat dry, damaged skin.

Finally, nourishing Tocotrienols, a superior form of vitamin E:

  • Delivers antioxidant and emollient benefits
  • Help repair sensitive or dry skin
  • Improve skin’s overall health
  • Impart a vibrant and rosy glow

Ingredients of Neuropeptide Firming Moisturizer

Aqua (Water), Taurine, Isopropyl Palmitate, Cetearyl Alcohol, Phosphatidylcholine, Palmitoyl Carnosine, Ceteareth-20, Glyceryl Stearate, PEG-100 Stearate, Pyridoxamine Dihydrochloride, Dimethicone, Phenoxyethanol, Caprylyl Glycol , Tetrahexyldecyl Ascorbate, Resveratrol, Disodium EDTA, Pantethine, Elaeis Guineensis (Palm) Oil, Tocotrienols, Sorbic Acid, Sodium Hyaluronate, Tocopherol, Astaxanthin, Parfum (Fragrance).


Application of Neuropeptide Firming Moisturizer

Neuropeptide Firming Moisturizer should be applied both morning and evening. Dr. Perricone recommends applying the firming face cream liberally to the face and neck.

Neuropeptide Firming Moisturizer complements other products from the RX4 Restore line: Neuropeptide Facial Conformer and Neuropeptide Eye Contour. It’s also a perfect complement to the RX2 Correct and RX3 Repair regimens.

Recent Reviews of Neuropeptide Firming Moisturizer

Love it! – “Can’t live without this product. You instantly feel it working and a little goes a long way, as does all the products in the Perricone line. You can actually feel it working. Wouldn’t be without it, even if I had to skip eating out, I’d rather spend my money on this product.” —From Sephora

Worth every penny – “I have found through regular use and twice a day (you need only a dime size amount) that this is the BEST moisturizer on the market today. Like others, I have tried everything, but when I received a couple of samples of this product, I loved it immediately and purchased the product the next day. This was a month ago. My skin has never been the same. I am 50 yrs old next month and I have the skin of a 30 yr old. I had deep wrinkles around my jowl area and a few on my forehead…not anymore, I can honestly state that I am wrinkle free and it is because of this powerful moisturizer.” —From QVC

Sticking to this – “I have used this for 4 months. I never feel this contented with any skincare creme before trying on this one. It is excellent. Far beyond expectation. I like the smooth feel and texture of my skin after applying it. I think I will stick to this one. No switch to anything else.” —From Sephora

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56 Comments • Please comment below


  1. Glad to be back….
    Read one of Dr. Perricone’s books 8 years ago and used products religously and they were great. Family illness lost my way. 53 good skin but ready to do better. Orderting QVC’s 15 winkle/neuropeptide for 149.00…love products and samples
    Thank you……

  2. Way too expensive. I don’t believe any product is worth that much.

  3. Hi there,

    I seen your product on QVC and would love to try them, especially the serum. I am sceptical of products like this but the reviews have got me interested!

    Kind regards


  4. i would love to receive a free sample of this. i don’t make a enough money to be able to order his line of facial products. also, i will be 55 this october and my skin is just not sitting where it used to sit. i have sagging jowls. i am a little person and my face just seems to be going south of the border and i am just uncomfortable with it. sitting here wishing i had the skin i had back in 2007. i am not liking what i see when i look in the mirror. please consider my letter for a sample of his free product or products.
    thank you.

  5. Dr. perricone has truly made the best products out there I would love to be able to try anything he has developed!!

  6. I used Pericone products a couple of years ago but stopped because of the expense. I am 63 years old and my skin is worse. I have enlarged pores and fine lines and wrinkles. eyes are also showing the age. I sae Dana (?) last night on QVC and she is absolutely beautiful. Her skin glows and lights up the room. Does she wear makeup? I would love for my skin to look 1/2 as good glowing and clear as hers. I want to start the products again , what to use when..

  7. I am 44 yrs old and I recently had an IPL/Matrix treatment and boy was that a mistake. My skin texture is worse and I have lost elasticity and have more fine lines than before the treatment. I look older and it breaks my heart! Now, 3.5 months later, I am searching for products that will improve my skin to get it back to where it was before the IPL, and even better. I eat a healthy diet, I do yoga, and recently I bought the book called “Yoga Face”. Now I just need some good quality products that will help my skin to heal and glow. As you can see, i am serious about good skincare and I would love to test the Dr. Perricone products.

  8. After having a year like this I need with my skin

  9. Just starting my quest to turn back the hands of time.54 years young and now its time for me.Boot Camp, healthy eating and now if I could add Perricone? That would be perfect.Thanks!

  10. I am a 61 year old woman who has always taken care of her skin.Five years ago, after having breast cancer and 16 chemo treatments my skin became very dry with wrinkles around my eyes, deep forehead creases,some sagging and looking very tired.If you pick me to become a Perricone tester and the products do everything they say they do, I will buy them and tell all my clients (I am a hairdresser) and friends how well they work.I usually stick to one product line but nothing has been working that well. I have read Dr. Perricone’s books and have seen his products on QVC and they just seem too good to be true.Because of how expensive they are I am afraid to buy them without trying them first.Please pick me as a Perricone tester so I can try this miracle cream…neuropeptide firming moisturizer…this would make me so happy!

  11. I have alot of friends who have lovely skin, some are helped along the way with botox and collagen and some just have great skin thanks to their mum or dad.
    I cant thank my mum or dad for my skin and I cant afford the other! I feel my skin would really benefit from this range. Would love to try the dep wrinkle serum, the firming moisturiser and the cold plasma.
    I just look older than I am.

  12. I love the Perricone products. I buy them from the Shopping Channel in Canada. Just received the new Neuropeptide firming moisturizer and it feels really great on my skin. I also love the cold plasma and the high potency evening repair. I also just received the no foundation foundation and I have just used it once, love the glow, I am 57 and don’t like the consistancy of most liquid foundations. Wish there was somewhere in Newfoundland to buy locally. Best products I have ever used.

  13. I purchase a lot of perricone, now I am moving towards the deeper wrinkle items and want to test before spending that kind of money. Once I find a working product, I stick with it. Perricone is expensive, but if it works, then its worth the expense.

  14. Since I owned a skin care/makeup company a number of years ago, I learned from first hand experience how important a good regime is to keep skin looking vibrant, smooth and clear. After turning my company over to someone else to run, I started experimenting with other brands and for years now I have used Creme de la Mer and, more recently, started with Caudalie, Peter Thomas Roth, DDF, Dr. Denese, however when I last received my High Potency Evening Repair and Amine Complex from your website, a small sample of Neuropeptide Firming Moisturizer was included. I could not believe how smooth, clear and soft my skin is while “very sparingly” using the product. The other brands are good, and look very nice under makeup, but this product is actually “improving my already good skin”. I am thinking about ordering this when I finish my current skin care products and, of course, would love to be sent a complimentary jar! Very nice, effective moisturizer! By the way, last week when I visited our local Sephora store, your representatives were there to give consultations and I sampled the Neuropeptide Eye Lift Synergy duo – also, very, very nice!!!

  15. This is the product I`ve been waiting for a long, long time… Reading the other customers opinion, I believe that there´s nothing like it, in terms of recovery and furbish of skin. I have many acne´s scars, that are getting better with Advanced Face Firming. Now I would like to try the RX4 regimen but the prices prevent me. If I get this sample I´ll write back in the site to give my avaliation, with the challenge of, someday, buy the 3 bottles of RX4. Thanks for giving me the notion that cosmetology isn´t only about appearance but most of all, it is a TREATMENT for body and, consequently, for the soul too. Mônica

  16. as a woman in her mid-thirties who’s always looked much younger than her true age .. the wrinkles seem to have snuck up on me overnight! ACK! i would love to try the Neuropeptide Firming Moisturizer in hopes that it can be the winning partner in my battle against aging skin!

  17. I am a true 44 year old vitamin and face product fan. Of course I know I will never look 20 years old again however I do try to take good care of my skin and can’t seem to find that one product that really produces results. I just happened to be flipping channels last night and saw Dana( I believe that was her name ) representing Dr.Perricone on QVC. Her skin was absolutely gorgeous ! She had the most amazing skin and that is what I am looking for , glowing and healthy! I would love to have the opportunity to see if this is the product that will give me the glow of healthy skin. Thanks for making me a possible future customer.

  18. Deseo utilizar tu producto, mi rostro se encuentra reseco y con arrugas. Espero poder conseguir este producto.

  19. Hi.. I’m not going to beg to try your product but it looks like a great one. I know that if I am chosen to try out your products and they show good results, than you will have plenty of my friends, relatives and co-workers buying this product also.. Hoping to here from you Linda 53

  20. I just turned 47 and although I have always taken care of myself and my skin, lately the old gray mule just ain’t what she use to be. I am at a crossroads and have started Dr. Perricone’s 28 day regime but just can not afford the neuropeptide cream! I’ve read that it is wonderful and would love to add it to my new routine. Please consider me as one of your testers.

  21. I would LOVE to win the Neuropeptide firming moisturizer. I bought the Forever Young book, altered my eating and supplements, got Cold Plasma face and eye and cleanser. My skin has really changed since I had radiation cancer treatments and the drugs and I’ve just dried right out looking much older than my 57 years I think. I KNOW I can get a healthy body, mind AND skin by following Dr. Perricone and this moisturizer would be just one of the steps. Merry Christmas all.

  22. I have bought your Neuropeptide firming Moisturizer , I LOVE IT, I am in my 40;s, but as a sun baby for most of my life i have damaged / frekeled skin, Due to being a competitive swimmer and life saver most of my life in the harsh Australian Qld sun. This Stuff has made my skin more supple and has Evened out my skin tone, It hasnt got rid of the Frekels but they have faded.. I would recommend this to Anyone who wants a Quality skin moisturizer that Works

  23. I am a woman of color. I have no wrinkles but do have discoloration, dry skin and enlarged pores. I have tried other products but am having difficulty finding something designed for my skin type. I have seen your picture and am always amazed at your skin.
    Please allow me to try your products to see if they would work for me.
    Thank you!

  24. I have “pretty good” skin for someone who’s 60+ and fair skinned. I could definitely use some help with brightening and evening out skin tone though. Your Neuropeptide Firming Moisturizer sounds like it would do that and then some. I’d certainly like to give it a try.

  25. At 45, my skin isn’t what it used to be. I’ve
    noticed gravity is taking a toll on my face
    and I’ve developed jowls! Yuck! I feel that the Neuropeptide Firming Moisturizer would greatly benefit me!

  26. I am 60 yrs old. I have been asked to be an attendant in my niece’s wedding on October 1, 2010. I HAVE to wear a long dress that is sleeveless and bears my shoulders. I take good care of my health. Have JUST received an excellent lab work from my doctors. My arms are thin but have raisen-like appearance and are very unattractive. I want to use a cream that will help my arms look better for the wedding and so I can wear sleeveless tops at least 10 more years. This would give me confidence when I walk down the aisle on my niece’s wedding day. The other attendance are much younger – my niece has a special place in her heart for me and just had to ask me to be an attendant. Please, please consider me. Thank you for your time…. Eva Vega

  27. have never tried this product, but would definitely like to! I am a 57 yr old female with a 30 yr old outlook! I strive to take care of my skin but age does play a factor..would love to see how this works!

  28. I would love to be a tester. I know people that have used your products and love them. I would faithfully follow your instructions if I became a tester. Your products are wonderful but very expensive. I always want to look my best and I know with your products I could do just that. I exercise everyday by bike riding, swimming,doing yoga and walking my dog.I follow a sensible diet by eating lots of salmon, vegetables and fruits. I have totally eliminated meat and dairy products from my diet. I also stay out of the sun when I am not exercising. During my exercise outside, I apply suntan lotion with zinc oxide in it. I am extremely health conscious and now I am making an effort to keep my skin more youthful.

  29. I have not tried this product but after reading tne reviews,I am willing to try it. I will not buy large supply but would like to try a sample to see if it is all you say it is.

  30. This product is a need not a want. Before I started using this product my skin was dull, and dry. My skin didn’t look like I was 23 then I ordered a kit with this included and it been 20 days today since I am using this product along with a few more of Dr. Perricone’s products , also a balanced diet with lots of water and I can see a huge improvement my skin is dewy, soft soft, smooth, and the clarity is so much better that before. Thanks a million Dr. Perricone. I’m a true believer in your products and a loyal one!!!!

  31. Would love to be a tester for this product; I use other products in the line and am ready to step up to the next level. The fine lines and wrinkles are winning the battle – help me!

  32. Oh no! I turned 50 last week and I feel so bad about how I look – I need a miracle in a jar. I used to look ten years younger than my age and seemingly overnight I now look sadly, pathetically, exactly my age. I hope I win this!

  33. [...] Neuropeptide Firmining Moisturizer and Neuropeptide Facial Conformer, a $605 value, for just [...]

  34. I have very fair skin and have been looking for a skin care line,that will enhance my skin. i would be interested in being a tester for your product. I tried your firming moisturizer and liked it.

    Thank You

  35. I am a former patient of yours when you had your office in Meriden, Ct. I will be 65 years old now and take care of my skin. I am a swimmer – 3 times per week. I purchased your products on QVC to try them. So far I am pleased with them. I follow a special diet, don’t smoke or drink and stay out of the sun. I would love to continue to use your products, but I am concerned about the cost. It will cost $1000.00 to purchase the entire line.

  36. I have struggled with dry skin and am yet to find a product that works for my skin. I would love the opportunity to sample the neuropeptide firming, the description fits exactly my desires in a lotion and I really hope this product is as lovely as everyone says it is.

  37. Is this the liqued gold? I’m 37 and would love to be a Perricone tester. I would be a good client for product review. let me know how I can help and if I can receive this product to review? Thank you. AB in NJ

  38. Having gone through menopause, my skin needs anything and everything. I have drawers full of products making extraordinary claims and none seem to help. This product might possibly be “the one”.

  39. I love this product! I have tried several different products that claim to do what this does. THEY DONT! Not Dior, L’Occitane, or Ole Henriksen. This stuff is amazing!

  40. I now use 3 different moisturizer products(layered)–it’s hard to believe that one product would work!

  41. after reading about the advances of skin care. i have wanted to try a neuropeptide lotion or serum and dr. perricone’s seems to be on the cutting edge of the industry, offering advanced treatment and care products. i would love to test this and report my daily findings. thank you.

    los angeles, ca

  42. I have always been a Perricone follwer. My sister uses the LaMer product and we have a bet going on whose product is the best and which one gives the best result. I would like to try and use this product (Neuropeptide Moisture)to prove her WRONG

  43. Please pick me the try this wonderful product. I use a lot of your products and they really work!!!!!!!

  44. Help, I’m only 50 and I look like a turkey. I wish I could tighten my neck without going under the knife. I’ve heard your products are great and I really want to try the face firming moisturizer. I believe the testimonials. I am willing to try anything at this point. I’ve been using olay proX and I don’t see any changes. Please pick me.

  45. I would very much like to try this product. since i had my hysterectomy and went through menopause my facial skin has changed and started to sag. I was told i wasn’t a good candidate for estrogen. so i have lost a lot of my elasticity in my skin.

  46. Changed my entire routine to Perricone and dying to try this product!

  47. I just ordered your Cold Plasma Products on QVC. They’re saying you should follow with the Neuropeptide Moisturizer for great results. I am anxious to try it. I have developing lines around my lips and crow’s feet. I would love to have the wrinkles less noticeable.


  49. At 56, my skin has lost the glow it once had and because I love the beach and sun, the wrinkles have gotten pretty noticeable. I have tried a couple of products and love them. I would love to win this product to get the glow back and make the wrinkles a little less noticeable. Thank you in advance for the opportunity to win one of your amazing skin care products.

  50. I am 53 years old and of course have aging skin.I am trying to avoid plastic surgery and trying to use preventitive treatments. I have never tried Perricone products, but I would like to. I have slight crows feet and some fine lines around forehead. Would like to be a tester since the anti-aging products are so expensive. Thanks for your consideration.