Perricone MD – Neuropeptide Facial Contour (Discontinued)

Need to restore your mature skin to its more youthful appearance? Consider the Neuropeptide Facial Contour, the non-surgical face lift, with its ability to help create the appearance of chiseled cheekbones, jaw line, throat, and decollete areas.

Made for those with more advanced signs of aging, this formula contains neuropeptides and high levels of DMAE.

Comment below on why you want to try Neuropeptide Facial Contour for a chance to win it!

Want to learn more about Neuropeptide Facial Contour?

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What are Neuropeptides?

Did you know that without neuropeptides, communication in the brain, let alone throughout the body, would not function properly?

Neuropeptides are released by brain cells either as neurotransmitters, chemical substances that send nerve impulses across synapses, or as hormones, which affect the functions of receptive organs or tissues when transported to them.

While neuropeptides can produce pro-inflammatory or anti-inflammatory effects, neuropeptide Y has the opposite effect of its counterpart, pro-inflammatory Substance P. Among its benefits for the brain, neuropeptide Y lessens anxiety and depression; and what is therapy to the brain is therapy to the skin, so neuropeptides also prove helpful for your skin.

SAVE at checkout! Use EXCLUSIVE Perricone coupon codes and save!

A neuropeptide cream has the ability to help:

  • Decrease sagging, fine lines, and wrinkles
  • Reduce discoloration and dark under eye circles
  • Revive dull, lifeless skin and instead, maintain a fresh and rosy appearance
  • Protect skin from free radicals

Besides neuropeptides, this formula contains DMAE and phospholipids.

Other Ingredients

Like neuropeptides, DMAE also tones skin and improves resiliency. DMAE offers contouring benefits and helps diminish the appearance of fine lines and wrinkles.

Phospholipids allow for quick absorption as they mimic lipids naturally found in skin. They also repair and hydrate damaged, fragile skin.

Aqua (Water), Lecithin, Isopropyl Palmitate, Cetearyl Alcohol, Dimethyl MEA (DMAE), L-Tyrosine, Glycerin, Ceteareth-20, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Glycolic Acid, Phenoxyethanol, Caprylyl Glycol, Magnesium Aspartate, Zinc Gluconate, Disodium EDTA, Elaeis Guineensis (Palm) Oil, Tocotrienols, Sorbic Acid, Copper Gluconate, Tocopherol, Pentapeptide-18 (Neuropeptide), Parfum (Fragrance).

How to Apply Neuropeptide Facial Contour

To help ensure more chiseled cheekbones, jaw line, throat, and decollete areas, pat Neuropeptide Facial Contour gently on targeted areas of the face, focusing especially along the contours of cheeks, forehead, and jawline.

Recent Reviews

Wow – “It will last a long while. I use the original packaging @ 2.5 oz. and that lasts 7 ~ 8 months at least. This is the only product that has diminished the eleven lines between my brows. I actually use it all over my face, not just targeted areas.” —From Sephora

Stop right here – “I love this creme. It has made a miraculous transformation in my skins tone. I saw visable results with the first applcation [sic].” —From Sephora

Asked if I had work done – “I love all of the perricone products but especially the contour and conformer. My girlfriend asked if Ihave [sic] work done on my face – it was looking that good!” —From Sephora

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107 Comments • Please comment below


  1. I’ve been exploring for a little for any high-quality articles or weblog posts on this sort of area . Exploring in Yahoo I finally stumbled upon this site. Studying this info So i’m glad to express that I have a very excellent uncanny feeling I found out just what I needed. I such a lot undoubtedly will make sure to do not forget this site and give it a glance on a continuing basis.

  2. I would love to test products and receive discounts so that I may afford to continue use. Just started using the neuropeptide cream and neuropeptide for decolette. So far so good. I am sure I will see great results with continued use.

  3. Need some help with sagging skin around the nose cheek area. would love to try product!

  4. I’ve been using the neuropeptide face cream for the past year. Brown spots on my forehead have faded dramatically. I could use some help to eliminate the lines above my upper lip, but I think the neuropeptide is helping with that too. I am 58 years old. I also use the face moisturizer and am hooked on the No Foundation, foundation.

  5. i need this product because i am an aging black women (60) years old. I have free radicals, sun damages, laugh line wrinkles and dark circles under the eyes. I believe these aging signs qualify me to become a perfect product tester for Perricone. thanks

  6. i need this product because i am a aging women almost 60 years old. Free radical, sun damage, laugh line wrinkles and dark circle under the eyes i believe these aging sign qualifies me for a product tester.

  7. interested in jawlinw tightening.

  8. i have been using dr. perricone products just over a year now from
    the shopping channel in canada i never have any untoward effects
    no stinging burning or redness i have tried elizabeth grant 3 times
    ane every time i had to quickly remove the product from my face
    it burned very badly especiallyt around orbit of eye even tried her
    lip stain and got a static burn sound insane but it was like an electric shock i have 3 kits of dr perricone on auto delivery and love them all

    sincerly leanne

  9. i am 47, medical doctor, upper lids, deep nasal creases, under eye dark spots, and everything according my age, always looking for something new, effective, that i can recommend to my friednds and my patients.

  10. i am only 30, but honestly my main problem is not so much wrinkles (besides the sagging skin under my chin and neck, yuck) but terrible blackheads and acne that i literally have never been able to once get rid of. NOTHING, and i mean nothing has ever worked. i have three kids and am a single mom so i honestly can’t afford any of your products so i would never have a chance to try them no matter how bad i wanted to :( i wouldn’t even know what to say if i was offered to try something for free?!

  11. I am 70, do not have wrinkles, I have used retin A for years, but I do have bags under eyes, deep creases and sagging jowls. I would love to test your products.

  12. I am 43 and starting to see serious lines and puffiness, especially around my eyes. I have tried numerous products with no effectiveness.I would love the chance to try this product.

  13. I haven’t seen Neuropeptide facial contour. I currently use Neuropeptide facial cream. Is it safe to assume it is the same product? The cream is awesome. I just love every product I use of Dr. Perricone’s. My favorite is the Neuropeptide facial cream. It gives my face a facelift. It has taken care of all of my freckles and discoloration, fine lines and most of the deep wrinkles. I get so many compliments on my skin since I started using Dr. Perricone products. I would love to become a product tester.

  14. I am over 60 but as an ex actress wish to maintain my looks. I have tried other good quality creams but I find none of them actually act as a complete skincare dealing efficiently with deep wrinkles and sagging skin at the level I need and the Perricone range is based around a more serious ethos of caring for womens skin. I have just purchased Perricone products as special offers from qvc but would like to continue using the range. I have been ill for some years and have had time to follow my interest in health and beauty at home. My experience is wide and my interest in the range has come about as thinking ‘this is my last chance to find an efficient skin care range that will make me feel more confident. Thank you

  15. Time is passing! I have always had good skin but changes are occurring that I have escaped until now–mainly sagging! I will be 72 this month. What a birthday present it would be to reverse what is happening.

  16. I am 56 – like most am searching for that one skin regime that truly works. I take care of myself and at some point will seriously consider cosmetic surgery so my face does not totally plunge into senior abyss. I can honestly say I have tried just about every single brand out there including some of Perricones years ago and just recently have become intrigued by the Cold Plasma – which by the way is how I came across this site. There is definite slackening of the jaw line…..the tone of the skin is changing showing more fine lines overall with creases in the forehead finally becoming more apparant. The undereye area shows beginnings of definite tear troughs due to skin slackness.
    I have read recently about the importance of peptides and look forward to trying this in my fight against skin slackness.
    I would be a great candidate as a Perricone tester. I would be precise and thorough in my analysis. I look forward to experiencing the total effects of Perricone.

  17. It’s difficult for feel so youthful but show otherwise on the outside. Who cares, you say? I care, I care a great deal. I am very conscience of what goes into my body and would not jeopardize any health risks to look or feel any younger. Simply not worth it. But I’ve been reading about this product and there are wonderfully healthy components to your product. I think trying it would be an honor.

  18. I’m 51 but feel like a 20 year old and would like to look more like I feel. Everything is staying in shape pretty well except the jowl line & wrinkles around the mouth. I’m hoping that I am using the right product – I’m going to give it a try!! If there is a better product for me, please let me know. Love to test before I invest :-) Thank you, Kim

  19. Hello Dr, Perricone,
    I am a Singer and Actor about to face my middle years and after many years of hard work finally becoming more successful. It is at this time in my life however that my age is beginning to show. I would love to maintain a more youthful appearance to elongate my career. Beauty and experience is a winning combination!

  20. I have sensitive skin, prone to break outs. Therefore I’m very conservative when trying new products. I would love to try your anti aging (fine line removing) products.

  21. hi, just found this blog as i’m always searching for a good product to restore my skin that for the past 2 years has shown alot of aging since i had a complete hysterectomy 2 years ago. my eyes and areas between my nose and chin are now showing wrinkles some sagging. it’s so hard to accept this since i used to get such compliments on my skin from even strangers. but not now, i can’t even find a decent makeup that makes my skin look better. i am hoping your neuropeptide facial contour would help alot. i am almost 75 this year and in good health, eat right and excercise ,too and would love to be a tester for your product. if this is not possible, could you at least send me a sample of this product? i really need something to help alleivate these signs of aging. thank you, ruth

  22. I have tried so many creams and I never get results. Therefore I am very skeptical. Before I purchase a skin routine this pricey, I have to know for sure that it works. I would be honored to be chosen as a tester. I am 60 years old. Thank you.

  23. I have tried so many creams and I never get results. Therefore I am very skeptical. Before I purchase a skin routine this pricey, I have to know for sure that it works.

  24. I am 56 and look much younger according to other peoples comments. I would like to buy or test the neuropeptide facial contour conformer. I eat only organic foods and always look for natural approaches.

    Thank you,

  25. I love your products as they are the only ones that do not 1) turn me red 2) cause breakouts and 3) burn… and they make me look the way I was meant to look:) Im actually so pleased with the product line I am commenting to have a sample given to my mom because she still uses plain glycolic and I believe this would transform her pretty skin into firmer skin. How about it? If I dont win the sample, thanks for giving me skin-confidence!

  26. I was lucky enough to be able to get the Neuropeptide cleanser, serum and firming moisturizer as a special on one of the shopping channels. OMG I am scraping the bottom of the bottles! Unfortunately I’ve become unemployed (at 58 makes it even harder to get a job) and at the present these products are the ultimate luxury. That being said I would love to try anything and everything possible. I, however, will find a way to continue using Perricone. Nothing, nothing, nothing compares.

  27. Frustrated by throwing money away on many touted,expensive products.I am 70 with beautiful skin which I have always had but in the last year pores are larger and some sagging beginning aruund jowls
    Would love to try prduct before I invest!

  28. I would love to sample this product. I have wasted hundreds of dollars on products that didn’t do a thing. I would love to try your product before spending the money. Thanks so much. BTW, I am 54 and have been searching for something to help me with my neck!

  29. I recently turned 40 and actually have great skin. However, I am seeing some increased pores, forehead lines and some sagging around the chin line. My mother who is 61 swears by this product and I would love the chance to try it as well!

  30. i would like to try neuropeptide facial contour please.

  31. Turing 55 this yr. weighs heavily on my mind. Since my teen yrs. I’ve been complimented on my beautiful complexion but the sagging skin, especially around my jawline and throat gain little notice now. I’d love to test your Contour cream and possibly turn back the hands of time (if even just a tiny bit!) I’ve enjoyed your products over the years & would love to add this coveted prize to my “mini black doctor’s bag” of treasured products!

  32. I used Mary Kay products for thirty years, and now a faithful user of Lancome products. After seeing your QVC show and demo of products tonite, I would like to compare by trying your neuropeptide product. I am soon to be 58 years old and am in perfect health. I would be interested in trying your product and commenting back for you. Thanks!

  33. I am 48 years old, everyone i meet thinks that i am older than my sister. She is 57 !!! I would love to sample your products and see if it could change things around. For once in my life i would like to look younger than her, because i am younger !!! This has been going on for about 20 years now. Please Help… Thankyou

  34. I would love to try this product. I would be willing to do befores and afters of the products effectiveness. Please consider me as a tester of Dr. Perricone’s products.

  35. I am a 46 year old single woman and looking my best is very important to me. I have read Dr. Perricone’s books and follow his anti-inflammatory diet. I am told I look 10 years younger than my acutal age and I would like to continue looking younger. I would love to test the Perricone products!

  36. O-M-G! I want to try this because I NEED this – ‘things’ are going South on my face that are not supposed to be that low – primarily below my cheekbones and jawline!!! I’ve heard lots of great comments about it, and I’d sooo like to try it for myself – everything else of Dr. Perricone’s that I’ve tried is great, so…. PLEASE — PICK ME!!! ;-))


  38. Have been using a regimen of Perricone MD products, but can has not helped with aging on neck and and lower jaws. Have recently read about neuropeptides being the answer. Would love to try this product!!

  39. I watched you on the Dr. Oz Show. I have researched the ingredients that are in the cream. I believe it would help to reduce the “parentheses” around my nose and mouth. I am 57 years old. I have diabetes and the neuropeptides have shown to have positive effects on diabetes (I’m just not sure if the topical cream will help.) I’d love to try a free sample of your cream to see the facial and diabetic results. Please. Sandra

  40. I would love to try this product. I’ve heard some great reviews. I have dark circles and bags under my eyes. I have recently noticed some sagging under my chin close to the throat area. To be able to improve my facial appearance just a little would be a blessing.

  41. Hi,

    I had chronic sun exposure during my childhood and teen years. As a result my face and decollete look much older than they should with pigmentation and creping. I’m looking for a product that will reverse some of the signs of aging. I have realistic expectations. Any improvement would be wonderful. I’m currently using a body butter with no active ingredients which keeps my skin moisturised but that’s about it. I’m searching for something more effective. Perricone’s Neuropeptide Facial Countour could be the answer. I’d be very happy to try a sample, thanks.

  42. As a single mother of three, I feel a bit worn down. Working full time and in my mid 40s running my children around, life is a bit busy. I would love to try this product as I once sold another type of facial moisturizers. Hoping to look younger soon.

  43. If you like Mary Steenburgen, you would like me, except I look like a “before” for Dr. Perricone’s products. SOS

  44. I hear that this is the Red Carpet Cream! I would love to have that Red Carpet Glow as do so many beautiful Women!!
    I have done so much research, and believe that these ingredients will ensure the maximum results!
    I am 44, and want to fight aging with everything I’ve got, so I would love to try this miracle cream!!

  45. I have just started to use the firming cream and would like to try other products.I am 60 and do not want to have surgery or injections, like using products.

  46. The Perricone philosophy, including nutrition and vitamins has always been ahead of it’s time. Dr. Perricone has taken into account the inside and out of the individual, and I have always appreciated his holistic approach; looking and and feeling good go together, we can’t just ignore what we put in our bodies, the efficacy of the product used is doubly enhanced by the Dr. nutritional advice and vitamin line.

    These products are life changing; positively effective. They are the only products that I have used that live up to the promise of dramatic improvement and enhanced, healthy skin.

  47. I would be thrilled to be a tester for this product. I have been a regular user of your products for the last 3 years and would not give them up for anything. I am 66 and definetly at the age where I probably need to start using a contouring facial product in addition to the other Pericone products that I currently use. At this age many women consider plastic surgery – many do not. Some of us would just like to be the best we can be without it. I think that anyone using your products is concerned with the healthy look of their skin at any age.


  49. I am a 46-yr old wife and mother of 2 teens! I have always keep meticulous care of my skin and it has paid off! I believe that I look very young…WITH THE EXCEPTION of some creping and sagging of my jowls! I think that it ages me so much…would love to try the contouring product !!!

  50. after I had been sick for a while,I realized that my cheeks was sagging, and I had tried so many products, nothing really worked, until one day Mecca shop offered me to try this product, it’s really effective, my skin is tighter and more lifted. I use it as a serum, I am not sure it is right, some people use it before the make up thought.