Perricone MD – Neuropeptide Facial Contour (Discontinued)

Need to restore your mature skin to its more youthful appearance? Consider the Neuropeptide Facial Contour, the non-surgical face lift, with its ability to help create the appearance of chiseled cheekbones, jaw line, throat, and decollete areas.

Made for those with more advanced signs of aging, this formula contains neuropeptides and high levels of DMAE.

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What are Neuropeptides?

Did you know that without neuropeptides, communication in the brain, let alone throughout the body, would not function properly?

Neuropeptides are released by brain cells either as neurotransmitters, chemical substances that send nerve impulses across synapses, or as hormones, which affect the functions of receptive organs or tissues when transported to them.

While neuropeptides can produce pro-inflammatory or anti-inflammatory effects, neuropeptide Y has the opposite effect of its counterpart, pro-inflammatory Substance P. Among its benefits for the brain, neuropeptide Y lessens anxiety and depression; and what is therapy to the brain is therapy to the skin, so neuropeptides also prove helpful for your skin.

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A neuropeptide cream has the ability to help:

  • Decrease sagging, fine lines, and wrinkles
  • Reduce discoloration and dark under eye circles
  • Revive dull, lifeless skin and instead, maintain a fresh and rosy appearance
  • Protect skin from free radicals

Besides neuropeptides, this formula contains DMAE and phospholipids.

Other Ingredients

Like neuropeptides, DMAE also tones skin and improves resiliency. DMAE offers contouring benefits and helps diminish the appearance of fine lines and wrinkles.

Phospholipids allow for quick absorption as they mimic lipids naturally found in skin. They also repair and hydrate damaged, fragile skin.

Aqua (Water), Lecithin, Isopropyl Palmitate, Cetearyl Alcohol, Dimethyl MEA (DMAE), L-Tyrosine, Glycerin, Ceteareth-20, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Glycolic Acid, Phenoxyethanol, Caprylyl Glycol, Magnesium Aspartate, Zinc Gluconate, Disodium EDTA, Elaeis Guineensis (Palm) Oil, Tocotrienols, Sorbic Acid, Copper Gluconate, Tocopherol, Pentapeptide-18 (Neuropeptide), Parfum (Fragrance).

How to Apply Neuropeptide Facial Contour

To help ensure more chiseled cheekbones, jaw line, throat, and decollete areas, pat Neuropeptide Facial Contour gently on targeted areas of the face, focusing especially along the contours of cheeks, forehead, and jawline.

Recent Reviews

Wow – “It will last a long while. I use the original packaging @ 2.5 oz. and that lasts 7 ~ 8 months at least. This is the only product that has diminished the eleven lines between my brows. I actually use it all over my face, not just targeted areas.” —From Sephora

Stop right here – “I love this creme. It has made a miraculous transformation in my skins tone. I saw visable results with the first applcation [sic].” —From Sephora

Asked if I had work done – “I love all of the perricone products but especially the contour and conformer. My girlfriend asked if Ihave [sic] work done on my face – it was looking that good!” —From Sephora

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107 Comments • Please comment below


  1. I really would love to try your cream, always looking for a product to make me look younger.

  2. I read the “The Wrinkle Cure” many years ago and love Dr Perricone’s real science behind what he sells. I also loved that he came up with certain fruits you can eat to give your skin that anti-aging boost. I struggle with hiperpigmentation and crepe skin under my eyes. :0 Aging is not for cowards!! I”d love to try his products.


  3. i am almost 68 yrs old and i look great thank you Perricone products. a little pricey for me so i use sparingly. have not found a product i do not love.

  4. Yes please send me new products to test. I have alittle sagging and new to contour my jar line again. Also little acne scars and I am 62.

  5. I used yo use the contour and it was great! Please bring it back. I’m 53 and it made a hugh difference.

  6. I’m a Perricone freak! Actually in a licensed but non- practicing estitician therefore a certified skin care junkie. I’ll be 52 in December so the very challenging is in full swing. Researching and reading new technology is my thing. I’ve been using Perricone for about 5 years now and wish i would’ve earlier. Among others I’m currently using the Neuropeptide decollete and still on the fence. I’m thinking the Sub D is superior. I only wish my budget was greater so i might expand my usage. Love the Perricone line! Thanks! Lynn

  7. I have sagging skin I look far older than my 56 years and find this very depressing. I also have acne scars that make me look older. I did use retin a when I was in my teens and early 2o’s and this really helped my skin. However my skin is to dry now to use it. I would love to try something that could really tighten and firm my skin. Also anything that would lessen my scars.