Perricone MD – Cold Plasma

You’re an individual with unique skin care needs. Even if you and another person are both clinically healthy, one of you may need more of one type of nutrient than the other does. With this concept in mind, over the course of five years in collaboration with physicists at Los Alamos Laboratories, Dr. Perricone developed Cold Plasma, a revolutionary product to help enhance your current anti-aging routine through the power of biochemical individuality.

What is biochemical individuality, and how does this revolutionary product, Cold Plasma, work?

Learn more:

Try Perricone for as little at $10.

Cold Plasma is a universal skin care product; suited for anyone, no matter how old your skin is, what your skin type is, or whether you’re male or female.

Cold Plasma works through a patented ionic (i.e. charged particles) suspension carrier system which allows for your skin to extract from Cold Plasma’s formula according to your individual, unique needs. This personalized system, called biochemical individuality, is a self-selection process charged by phospholipids, major cell membrane components. Phospholipids are fat derivatives which help lock in moisture, because phosopholipid bilayers have hydrophilic (attracted to water) heads facing outward and hydrophobic (mix poorly with water) tails facing inward toward each other. The phospholipids in this formula help direct needed nutrients where they can be effectively used through the cell membrane. This also means, if any of the ingredients aren’t needed, they just won’t be utilized.

Check out the latest Perricone sale for $10 samples!

Cold Plasma works through this system to deliver optimal nutrition to skin cells to help skin achieve a healthy, glowing, youthful appearance.

It does so by helping combat the 10 signs of aging, which include:

  1. Firmness
  2. Elasticity
  3. Clarity
  4. Radiance
  5. Smoothness
  6. Texture
  7. Redness
  8. Blotchiness
  9. Fine lines and wrinkles
  10. Dryness

Beyond the unique delivery system, the key sciences behind this product include:

  • Advanced neuropeptide technology to give anti-inflammatory effects, which assist in slowing the 10 aforementioned signs of aging.
  • DMAE to help stimulate nerve function, thus causing muscles under skin to tighten, providing a lifted and firm appearance to sagging skin.
  • L-tyrosine, an amino acid, brightens skin to help radiate a youthful glow.
  • DHA, an essential amino acid, to support the preservation and hydration of skin.

cold plasma

Cold Plasma contains no:

  • Parabens
  • Fragrance
  • Sulfates
  • Mineral oil
  • Artificial colors or fillers

According to Dr. Perricone’s recommendation, in the morning and evening:

  1. Cleanse skin, first
  2. Apply Cold Plasma
  3. Put on any Perricone MD treatment and/or moisturizer to finish

Can it get any better? – “I’ve been using Cold Plasma since its exclusive debut on QVC and have been amazed that my skin could actually look any better after five years on Perricone products. Yet it does! Brighter, firmer, smoother…all this and more…” —From

What a difference! – “Tone and texture has evened out, pores (which I was told mine were small, but were visible to the naked eye), are virtually diminished, I can only see them when I use the dreaded 10X mirror to pluck my eyebrows. The price is high, but the product goes very far, I am sold on the product, and will definately stay on the auto-delivery plan. I notice I am using less make up, so I figure the money will even out, in the long run. Its nice to get up in the morning and debate on even bothering with the make up…” —From QVC

Can’t live without it – “Great product, I highly recommend! I’m 40. I noticed a change in my skin tone, radiance and the big one– It softened my lines and wrinkles right away!!! This is a product I can’t live with out.” —From QVC

The Doctor is "in" on Facebook.

857 Comments • Please comment below


  1. I’m currently using Strivectin. I’ve only been using it for a two weeks. I wasn’t able to use the product twice a day at first because it broke my skin out. A skin consultant from Strivectin told me to use the product once a day until my skin adjusted.

    Now, I use Strivectin twice a day. I’m not sure if it’s working. The supply (which cost $80) is only a 2 week supply. I will need to buy more Strivectin or a new product.

    I want something that will reduce the appearance of my pores, the wrinkles around my eyes, hyperpigmentation from acne, and not cause more pimples.

    Would Perricone be a useful product?

  2. my wife would like to try the cold plasma. she feels with all the free radicals out there, she feels this product would work well for her. application appears to be very simple. thank you

  3. If you only buy one product, make it this one.

  4. I Love Perricone products. I use many of his products, haven’t tried Cold Plasma because I just can’t bring myself to spend the $, but would love to try it.

  5. I would love to become a Perricone tester. I am 62 years of age and if it is going to make a difference surely an older face would be better.


  6. I’m 55. I need help. Please tell me it’s not too late.

  7. Hello I would like to become a Perricone Tester – and test you products.

  8. I haven’t used it for very long .just got a sample .so far I love it can’t afford it !!But My kids said mom you need a eye cream!! so I went to look for one and got a free sample. Would be so happy to win a free sample mom of five 50 years old !!

  9. I am 55 years old but like to think i look and act 45 or younger due to my high level of physical activity, relatively good skin, and in that i am the mom of a teenager. However, when i hit 55 in march, i was appalled to notice that my chin line was starting to sag. And once i noticed it seemed to sag more and more. i pride myself on looking young and generally use no more than pure olive oil or pure coconut butter on my face (except when out in sun when i use a zinc oxide 30+ sunscreen). All of a sudden i am seeking miracle remedies and even considering a facelift! I came across your website when researching DMAE and would like to try your product and become a perricone tester. thanks!

  10. I have been using perricone for a year now and my skin although good before is now superb everyone comments and I have recommened so many people to these products,I have tried most things but find combination of cold plasma then neuropeptide facial. Cream and evening repair brilliant ,I also use nutritive cleanser and am now trying acyl glutathione .would love to be a tester for you Annette

  11. I am 56 – like most am searching for that one skin regime that truly works. I take care of myself and at some point will seriously consider cosmetic surgery so my face does not totally plunge into senior abyss. I can honestly say I have tried just about every single brand out there including some of Perricones years ago and just recently have become intrigued by the Cold Plasma – which by the way is how I came across this site. There is definite slackening of the jaw line…..the tone of the skin is changing showing more fine lines overall with creases in the forehead finally becoming more apparant. The undereye area shows beginnings of definite tear troughs due to skin slackness.
    I believe I would be a great candidate for testing Perricone’s products. I would be very thorough and detailed in my analysis.


  13. I havent tried it,i will as soon i save enough .

  14. I’ve never spent this much money on face cream but after taking the plunge, I can tell you that Cold Plasma is absolutely worth it. It addresses a lot of skin issues. I now love my skin and get loads of compliments on it. Yes, it smells fishy when you put it on, but the odor vanishes in a few minutes. If you think about it, it’s good that it smells natural and not like chemicals.

  15. I’ve heard a lot of great things about Perricone products and would love to be one of the lucky testers. I’m 44 and a country girl. I’m getting older now and looking for a good anti-aging skin program to keep my looks. This is a great way to do that and I would give some very useful feedback. Thank you so much for the opportunity.

  16. I had several cold plasma samples and used them for a month. Loved the results.

  17. I am a 55-year-old female and as most women my age, am starting to see the damage from my earlier years in the sun. I have very large pores on my cheeks, nose, and chin. In addition I have several areas with small broken blood vessels. Help! What product can I use to diminish these signs of aging. I am also starting to see signs of slight sagging in the jowls and cross-hatch marks and loss of the fat pad under my eyes.

  18. I’m a product junkie! I’ve tried them ALL – To be honest I used Cold Plasma for about a year and a half and LOVED it. However now around the holidays, I was thinking it’s just a little to expensive. After two days I could feel and see a difference in my skin – feels tight, dry but more importantly the number 11s, crows feet and jowls are coming back in one week without Cold Plasma. It little goes a long way and it lasts forever. It IS worth every penny!!! Somehow this magical potion figures out exactly how much moisture you need in the humid heat of summer or dry, cold winter months while plumping up your skin and in my case even while on medications that are made to dry out your skin. Like Dana says, with it you will never guess my age… now without it….. is why I need it!!!

  19. I will be a tester

  20. I would be honored to be a Perricone Tester especially the Cold Plasma for face or eyes. I just turned 30 and boy has my skin changed. I have to change my routine up. Never thought about this till now
    imnotarunner at gmail dot com

  21. I have recently started using the face firming activator, face finishing cream and nutritive cleanser and am loving the effects so far and the glow I have gotten to my face also. I started using Perricone because I felt I needed a skincare system that helps with all elements of day to day life 1 being stress and seeing as I have had a lot of stress recently (my dad passing away, My mum getting diagnosed with cancer and then 2 days ago my Aunt passing away and also me having 2 ops on my shoulder within 6 months (1 being an arthroscopy and then 5 months later having a full blown shoulder replacement at the age of 42 years young))plus due to being on morphine for my shoulder my sleeping pattern is awful. Some nights I don’t get any sleep and on a good night (without sleeping tablets) I get 3-4hrs with sleeping tablets I get maybe 6-7rs but don’t like taking them on a working day due to feeling lack lustre first thing in the day. I decided I definitely needed a good product that was proven and not just full of false promises but a high price (I was using premium skincare before Perricone BTW) My skin before using Perricone had lost it’s colour and become very sallow (prob due to all the stress?) Since using this range my skin has blossomed I have colour back in my face my skin doesn’t look sallow and my skin doesn’t look tired and has a bloom. But I really think I need just that bit extra to get my skin back to how it was plump, glowing and smooth (although TBH I don’t luckily have many lines) So any help especially at the moment would be much appreciated (and 2012 to be a better year I think I’ve been through more than enough this year or even for the next few years!)xxx

  22. I am 42 years old. I have very big pores, more so than the average woman anywhere near my age. I also have loose skin and lines around my mouth and under my cheaks real bad. If this product would make the difference I would consider long term use. Anything is better than just accepting these ugly pores and the horrible signs of aging.

  23. I bought my first cold plasma on my tour in USa this summer…from the first moment of useing it, my skin is more tender, with more radiance and less wrinkles…It is great….Anna

  24. This product sounds amazing, targeting many areas of concern I have as far as skincare goes! I would love to try it!

  25. Live in Holland. Just ordered and received it through
    Babbasu. This is what a cream needs to do.
    Worth the money. thank you

  26. I just turned 50!!!!! and I’ve been dreading it!!!! Your products sound amazing!! can’t wait to try!!!

  27. such a great website!!! its very interesting and colorful! i just love it! keep blogging.

  28. Great product! Go and buy this! It really does work! It is refreshing to buy something that works!

  29. I tested this in the store and was amazed at how my wrinkles were not so evident. I went home and ordered it. I like the results thus far. I wasted more money buying other brands that never did what they stated. I can’ believe I found a product that actually works. Wow! Something that works what a concept! Thanks for delivering the truth!

  30. I am 53 with olive skin and as a result of a So. Cal lifestyle have plenty of sun damage as well as unbalanced skin (oily, scaly around the nose, dry patches.) I so identified with not wanting to look like a kabuki performer and learned about the value of DMAE and Alpha Lipoic Acid and purchased the No Foundation Foundation and Face Finishing Moisturizer. I also recieved samples of the Cold Plasma. Being accustomed to a full, obvious made up face it was tough to get accustomed to the new regimine. But a few short weeks later I am a convert. My skin is even toned, the area around my nose is clear (WOW!) and I have a natural glow as opposed to the heavy laden powdery look I had used for years. I would love to use any additional Perricone product – keep up the wonderful research and data based work!

  31. This seems almost too good to be true! I would love to try this product. I am 40 years old; I had near perfect skin without a pore or blemish until I hit my early 30s. It has been downhill from there. Free radical damage from smoking, sun worship, poor diet and hormones have ravaged my poor skin!!! I plan to read through the comments to see if there has been good success with this. I have been unemployed since January of this year so have to be very careful in what I spend what little extra money I have on! I would love the opportunity to test and review any of the newer products :)

  32. I’ve used and loved other Perricone products (especially the advanced face firming activator). Over the last couple of years, though, severe redness on the tops of my cheeks that has sent me in search of products to diminish redness. I’ve tried countless expensive products that promise to help, but they have done little to nothing to even out my face. The ones that have lessened redness have lacked any of the other skin benefits I want (pore shrinking, fine line reduction, firming).

    Is it possible that one product can tackle both severe redness and provide all the anti-aging benefits I loved in the other Perricone products? I’d love to find out.

    Cold plasma says it

  33. I’ve been watching QVC about your products…after going through menopause I noticed a big difference in my skin..more sagging..less firm. I’m 54 and looking for something to help me get back that youthful look…Thanks

  34. I just purchased from qvc the acyl-Glutathione this product is AMAZING!!!! it comes in a 1oz jar that supose to last you 3 months? dosnent look like it, maybe it would last me 2months if im stingy. but i just LOVE THIS PRODUCT !!!
    qvc was reccomending to use the cold plasma before the acyl-gluthatione i wanted to get it so much but could NOT afford it…
    Dr. perricone has the best of the best products, the only problem is affording several product all together. i WISH I COULD WIN THIS PRODCUT, it would be a dream come true

  35. I bought Cold Plasma as a sample. My skin has looked more hydrated and plump with fewer lines. I am 30 years old and I am a firm believer in prevention, and cold plasma has changed the way I look at skin care forever. I exclusively use these products and I am so happy with the results!

  36. I am so intrigued by Cold Plasma – it sounds amazing. I would love to try it on my 47 year old skin! My main concern is a lack of “radiance” – that youthful glow has gone and I would love to get it back. Cold Plasma sounds like the answer. I love the passion and science behind Dr. Perricone’s products.

  37. I have tried just but everything short of expensive treatment to try to reduce the size of my pores! But nothing seems to work. Though just about every product promises miraculously shrinking pores…really starting to lose hope. This seems like i great product and i would love to try it! :)

  38. I am 67 years old and I am getting age spots on my face and I have always had large pores. I have tried exfoilating and I have bought all kind of expensive products but nothing seems to work. I would love to try your products, especially the cold plasma. I have read all the reviews and it sounds like this would really help large pores.

  39. Love Dr. Perricone’s products, and this one sounds perfect for me. No parabens, no mineral oil…and helps improve skin tone??? Just what this 40something mom needs!

  40. I received a sample of cold plasma about a month ago. This past weekend my husband and I went out with some friends for dinner and a little gambling at our local casino. When we entered the casino we were asked for IDs immediately. I handed the girl at the door my ID and she said very loudly “you were born in 1971, what is your secret?” I just smiled and felt like I had already hit the jackpot! Please send me another sample please, please,please!

  41. I am dying to try this after seeing all of the rave reviews. I hope that it will help with redness and hyperpigmentation.

  42. I was confronted 3 years ago with Perricone creams in my friend’s house in Italy. My girlfriend skin looked always grey and unhealthy whatever she would do about it. And there the first time, she used the Plasma cream and I could see the difference. I was amaized and very happy for her. Therefore I have bought it too, and although I am 45 and always have had a good skin, I can see the difference… People tell me very often that I have a face of 35 ;-) and I am happy…

  43. I have used Dr. Perricone’s products for years. I have seen incredible results from all. However, when I used Cold Plasma for the first time, I was blown away. I didn’t have to wait through a second, third, fourth application to see how beneficial this treatment is. The smell was a bit much at first, but I soon got used to it and it no longer registers. Besides, it could smell worse and still be worth it. This is amazing stuff!

  44. I’ve been ordering the value sets to try the products first and there all so amazing how do you choose which ones to buy??

  45. I just saw this produc featured this morning on a talk show and I am convinced enough to give it a try! I have heard nothing but great things about Dr Perricone and I am also about to start his skin care diet. :)

  46. I was a major sun worshipper for many years, and at 39 someone asked if I was a grandma. I cried for 3 days straight, and am looking to test out any Perricone product that will help with my wrinkles. If you can make me look young again, I’m game!!

  47. I use the No Foundation Foundation and would love to try other Perricone products, particularly the Cold Plasma. Thanks!

  48. Have been using perricone products since they aired on uk Qvc and love them!after my second hip replacement(am only 46)skin took a dive so purchasedcold plasma and wow,just beautiful,products really work and are cost effective as you need such a small amount .

  49. As a birthday present this year, a dear friend made me the loveliest basket of items. I am a stay at home mom, currently coming through a long term marriage and divorce. I have two teenage sons, and beauty maintenance as a priority over the years has slipped! Well, my game is now ON! and so is my skin therapy *** the regiment is easy to use everyday; but my NEW LOVE is Dr. Perricone’s COLD PLASMA! I look like and feel like a new, fresher younger version of me!
    Thank you for the entire line offered, so many good elements pulled together to offer exquisite results! So happy to be a Cold Plasma for real tester!!! Looking forward to more amazing products coming from your labs! Way to go!!!

  50. I have read all of Dr. Perricone’s books, and am always his greatest cheerleader! I recently started writing reviews, and would like to opportunity to work with Dr. Perricone’s Staff to be an “Official” Product Tester. I would love to write about his products! Candy Darr ~ Stuart, Florida