Perricone MD – Cold Plasma

You’re an individual with unique skin care needs. Even if you and another person are both clinically healthy, one of you may need more of one type of nutrient than the other does. With this concept in mind, over the course of five years in collaboration with physicists at Los Alamos Laboratories, Dr. Perricone developed Cold Plasma, a revolutionary product to help enhance your current anti-aging routine through the power of biochemical individuality.

What is biochemical individuality, and how does this revolutionary product, Cold Plasma, work?

Learn more:

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Cold Plasma is a universal skin care product; suited for anyone, no matter how old your skin is, what your skin type is, or whether you’re male or female.

Cold Plasma works through a patented ionic (i.e. charged particles) suspension carrier system which allows for your skin to extract from Cold Plasma’s formula according to your individual, unique needs. This personalized system, called biochemical individuality, is a self-selection process charged by phospholipids, major cell membrane components. Phospholipids are fat derivatives which help lock in moisture, because phosopholipid bilayers have hydrophilic (attracted to water) heads facing outward and hydrophobic (mix poorly with water) tails facing inward toward each other. The phospholipids in this formula help direct needed nutrients where they can be effectively used through the cell membrane. This also means, if any of the ingredients aren’t needed, they just won’t be utilized.

Check out the latest Perricone sale for $10 samples!

Cold Plasma works through this system to deliver optimal nutrition to skin cells to help skin achieve a healthy, glowing, youthful appearance.

It does so by helping combat the 10 signs of aging, which include:

  1. Firmness
  2. Elasticity
  3. Clarity
  4. Radiance
  5. Smoothness
  6. Texture
  7. Redness
  8. Blotchiness
  9. Fine lines and wrinkles
  10. Dryness

Beyond the unique delivery system, the key sciences behind this product include:

  • Advanced neuropeptide technology to give anti-inflammatory effects, which assist in slowing the 10 aforementioned signs of aging.
  • DMAE to help stimulate nerve function, thus causing muscles under skin to tighten, providing a lifted and firm appearance to sagging skin.
  • L-tyrosine, an amino acid, brightens skin to help radiate a youthful glow.
  • DHA, an essential amino acid, to support the preservation and hydration of skin.

cold plasma

Cold Plasma contains no:

  • Parabens
  • Fragrance
  • Sulfates
  • Mineral oil
  • Artificial colors or fillers

According to Dr. Perricone’s recommendation, in the morning and evening:

  1. Cleanse skin, first
  2. Apply Cold Plasma
  3. Put on any Perricone MD treatment and/or moisturizer to finish

Can it get any better? – “I’ve been using Cold Plasma since its exclusive debut on QVC and have been amazed that my skin could actually look any better after five years on Perricone products. Yet it does! Brighter, firmer, smoother…all this and more…” —From

What a difference! – “Tone and texture has evened out, pores (which I was told mine were small, but were visible to the naked eye), are virtually diminished, I can only see them when I use the dreaded 10X mirror to pluck my eyebrows. The price is high, but the product goes very far, I am sold on the product, and will definately stay on the auto-delivery plan. I notice I am using less make up, so I figure the money will even out, in the long run. Its nice to get up in the morning and debate on even bothering with the make up…” —From QVC

Can’t live without it – “Great product, I highly recommend! I’m 40. I noticed a change in my skin tone, radiance and the big one– It softened my lines and wrinkles right away!!! This is a product I can’t live with out.” —From QVC

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857 Comments • Please comment below


  1. Cold Plasma is amazing. I 1st purchased a trial size from Sephora online. It was amazing. I wish I bought more as the trial package was a great deal. But, none the less, I found that my skin truly needed it. So, I splurged for the full size and now need another! Dr. Perricone was our family dermatologist for years in CT. My Great Aunt Nellie was a regular patient and had the most amazing and youthful skin. She said Dr. Perricone recommended foods to fight aging. Well, they worked and this was over 20 years ago. I saw Dr. P for fear of major scarring from a horrible case of adult chicken pox. Well, I am proud to say that the cream and regimen recommended worked! I fully endorse and would be a proud tester of any skincare product with the Dr. Perricone name.

  2. I just started to use a sample of Cold Plasma two weeks ago and I am so happy about the results already. My skin is firmer and bounces back. I had really dry skin and it is hydrated and plump in just two short weeks. I am 51 years young but was starting to see my skin age very quickly recently to my dismay. Now I have hope I can look as young as I feel!Thank you Dr. Perricone! Your products are amazing!

  3. I just bought the Cold plasma kit and used it twice so far. I cleansed with my Gentle cleanser, applied Cold Plasma, applied my High Potency Evening Repair and finished with my Intensive Moisturizer. When I woke up this morning my skin looked great and I cannot wait to see and feel the results within the next few weeks!!!

  4. would love to try cold plsma.. heard great things!

  5. I found cold plasma and use it faithfully – brush my teeth am/pm – use cold plasma am/pm – and lucky me – turning 61 and most people think I’m in my late 40/s or early 50′s – yes, I’m blessed with good genes but cold plasma is the icing on the cake – I need very little make-up because I have firm, radiant youthful skin – THANK YOU!

  6. Just started using the Cold Plasma three days ago and I already see an improvement in my skin tone and texture. My brown spots are fading quickly, too. Can’t wait to see my skin after a month. I’m 42 and have spent lots of time in the sun (and tanning salons…horrible, I know) but I’ve decided to stop wrecking my skin and try turning back the clock. I believe Cold Plase will be the answer to many of my skin issues :)

  7. Dr Perri cone’s product range continues to encourage and enrich the lives of those who male the effort to care for their skin. I have read that the cold plasma kills the bacteria on the skin. So, with this in mind one would believe that this in conjunction with other treatments can bring your skin back to a glow and even tone.

  8. I am 57 years old and recently went through a procedure to remove a large basal cell carcinoma mass from my nose. In treating the affected area I’ve noticed that my skin has started to sag, change texture and color, it seems overnight. I would like to test your products to slow the process of enlarging pores and rehydrate my skin. I’ve heard rave reviews about your products and would like to see it for myself.

  9. I am nearing the big 6…0…& am fortunate that apparently ‘I do not look my age’…that being said, in my research I have come to realise that a product that includes the ingredient DMAE would be helpful with regards to firmness & perhaps even muscle tone…I have never tried any of Dr. Perricone’s products but see that the Cold Plasma product & neck products may be the answer…& am looking forward to giving them a try.

  10. I am 52 years old and my skin looks very old.I would LOVE to see if cold plasma would work for me.

  11. I’m 52 years and while my skin has improved noticeably with a couple of the PerriconeMD products, I am now looking at finding the cream or product, to add a glow and elasticity to my skin. I would be so appreciative to try Cold Plasma or any other product. Should it deliver, I would pay the price with a smile!

  12. I am a 51 year old mother of five boys 28-10 years of age. A single mother for the past nine years, I have undergone much stress and it is starting to really show on my face. I have used your products before and had the greatest results. I would love being a tester because I know what a testimony it would be to your products because, when I was able to use them in a better financial state, I had nothing but compliments. Even my GYN complimented that I had “beautiful skin! and I have seen a lot of it!” Thank you for considering me.Cindy

  13. Lovely blog. I’d love to try that Cold Plasma!

  14. I love Perricone products and cold plasma is great – mostly I need this product to give to my young daughter so as long as she eats healthy takes her vitamins and uses Cold Plasma she will never have an skin problem to fix. The Perricone approach to beauty and health is the best.

  15. Would love to test your products!!!!!

  16. I have dark circles under my eyes, and under that I have bags. They have gotten worse w/the years. I am 60. PPL say I look 45-48 ish. The eyes give me away though. Can you help w/something for this. I have tried everything on the market and w/them not working at all and skin sensitivities, NOTING has helped.
    What to do??!!! :-)

  17. With the help from sales person at Sephora, I purchased items from Peter Thomas Roth, Dr. Brandt, and Dr.Perricone. I was most impressesd with Dr. Perricone’s skin care and plan to add the cold plasma to my list, plus the advanced eye firming cream. I am 74 and plan to continue to look in my 50′s.

  18. I’m 56 years old and I feel like my search for a great line of products is over. My skin feels back to normal and glowing again with some of Dr. Perricone’s products! Living in the desert is challenging for my east coast skin which drinks in Dr. Perricone’s products without irritation. I’m now following the diet and would love to experience the Cold Plasma ingredients on my skin.

  19. I am 37 and experience acne, sensitive skin and the beginning signs of aging. I would love to try this product to combat current skincare issues and ward of future negative showings of age.

  20. I purchased some products on the Perricone website and received Cold Plasma as a sample with my shipment. I am hooked! I have some acne scaring and uneven skin-tone and the tone and texture improved immediately with this product. It’s so nice to see results and find a product that delivers on it’s promise.

  21. Love cold plasma only after a few days!

  22. Have tried the concentrated restorative cream . Made a huge difference in skin tone and texture . Can’t wait to try cold plasma

  23. Sounds divine!!! Would love to try it!!

  24. I LOVE cold plasma. I got a sample from Sephora and was amazed at how it made my large pores almost disappear after one application. I wish I could afford it. It is way out of my price range. It may have to go on my wish list for Christmas.

  25. I have seen this product advertised on several blogs, and it looks great. I am now fifty, and I feel like it’s important to take proper care of my skin, before it’s too late. I have always used drugstore brands in makeup and skincare, but I now see the difference when I use high quality products.

  26. i am in my thirties and am having terrible skin problems…rosacea, acne, dermatitis. i tried the dermatologist, but her suggestions made it worse! i have tried many department store/md brands that seem to work for a few weeks and then stop. i would be really interested to see if perricone products would be the solution for my skin care woes.

  27. hello DR…..I am a 70 yr. old women who definitely does not want to look her age. I am very active and have tried so many prooducts on my face,neck, arms and etc. I’d love to try your product and will gladly purchase it if works. Best wishes to you and your work.

  28. Love, Love, Love Cold Plasma face and eye – excellent product. If you have tried a zillion products, and spent endless amounts of money looking for something that makes your skin feel like skin….this is a must try!

  29. Need this for my neck if it works like im reading I have a bit of sagging loose skin on my neck. Have been using Strivectin and have seen results would like to see. better .

  30. Like that Cold Plasma is non-greasy and light. Feels nice going on the skin and sinks in well. Have noticed more radiance and hydrated skin. I use this every evening and wake up pleasantly surprised.

  31. hi, can i apply cold plasma &/or high potency evening repair on my face after i had a diamond peel? thanks, and more power.

  32. Tried cold plasma( sample from Sephora) on my skin. The effect seen next morning. Excellent product!

  33. Cold Plasma is my spa treatment at home after a long day of being a boss, wife, and mom.

  34. Wow- this cream sounds fantastic! I’ve had a hard time finding a good anti-wrinkle cream that doesn’t break me out. I definitely need to try this one out!

  35. I would love to be a product tester for Perricone MD.. I have been using Obagi products for a little over a year and I’m growing concerned that this may have long term damaging effects. I spoke to a friend who raved about these products. I would love to try them.

  36. The cold plasma is the only product out of dozens that I have tried at various price points that literally erases all of my visible signs of aging, particularly the fine lines around my eyes. It is an amazing prodeuct.

  37. I am 55, my skin is not bad for my age don’t smoke and exercise but it is 55. this product was amazing . I tried it first asa sample in a Mecca store here in melbourne. instantly i saw a difference. Love its light weight texture and the fact it works. got the eye cream now

  38. Have always been complemented on my skin,recently felt that I had lost some vibrancy, I received a sample of Cold Plasma and tried it immediately, it has been two days now and even my teenage daughter has commented on wonderful my skin looks. It looks and feels great.

  39. I have mild-moderate discoid lupus. I really need a skin care system. That with help with the texture issues caused by this auto immune issue and the overall againg of my skin.

  40. It is not everyday that I receive a tiny sampler in my QVC order, however, I had my lucky day. I had ordered Dr. Perricone’s facial cleanser and toner. I was looking so forward to the arrival of these products. When they arrived I opened my “magic box” and “Bingo” included in my “magic box” was a tiny tube of cold plazma. I am 72 years old and had never used a product like this. I immediately started adding it to my daily regimen. I saw that it only took a tiny dab to make my eyes brighten up and come alive. Great job, Dr. Perricone, it is not every day a tiny sampler can realy make someones day. This great-grandmother now has bright eyes and a happy face.

  41. This is the best skin care I have ever used. It may be expensive but the results are over the top. In the long run the price and the cost is worth every penny. So don’t delay use Perricone it is by far the best skin care on the market!!!!

  42. Loved the sample of Cold Plasma that I got from a makeup website. Really noticed the difference in my skin.

  43. For years I’ve had red blotchy skin. At times even foundation won’t cover it. I received a sample of Cold Plasma with some products I had purchased though another website. All I can say is WOW! After just two days of using Cold Plasma, my skin feels softer and the redness is extremely diminished. I ususally don’t comment on products, but this is truly AMAZING!!! Thank you!

  44. For years I’ve had red blotchy skin. At times even foundation won’t cover it. I received a sample of Cold Fusion with some products I had purchased though another website. All I can say is WOW! After just two days of using Cold Fusion, my skin feels softer and the redness is extremely diminished. I ususally don’t comment on products, but this is truly AMAZING!!! Thank you!

  45. I want to learn more about which products are best for me. I am trying both the cold plasma and the cold plasma sub d. The cold plasma on my face seems to really tighten. I maybe haven’t used the d long enough yet as I do not notice much difference yet – hoping though!

  46. I am reading Dr. Perricone’s The Perricone Promise (I also have The Wrinkle Cure)& I really think I have found the solution to my cronic sleep disorder!!!!! I am a ‘sugaraholic’ & what I have read what sugar does to your system is astonishing!!! I am just starting the 28 day plan, so I am praying that this will help my sugar cravings as well as my ‘sleep problem’!I also now believe that this is why my skin is so dull & my marionette lines seem so prominent!! The only thing missing from the ‘plan’ is the neuropeptide supplement & neuropeptide cream….so maybe I will be lucky enough to win a jar of Cold Plazma to go along with my road to recovery!!! Thank you Dr. Perricone for leading me down the right path!!! :) <3

  47. Thank you, it is very interesting and useful! I will be the regular reader of your blog!

  48. I am using the cold plasma and face finishing moisturizer. I haven’t seen the results other users are describing. I suspect I am having a bad reaction to the fragrance in the moisturizer since I cannot wear most perfumes or use scented soaps. Any chance you can make a fragrance free moisturizer in the future?

  49. I will turn 70 in October, but I do not look my age….Most people believe I am at least 10 years younger. I exercise 6 times a week and try to eat a fresh healthy diet. Even so, I am seeing the effects of age on my skin…forehead lines,deep lines between my eyes, droopy eyelids, and fine lines in the mouth area, etc. I do not want plastic surgery and so am looking for a less invasive option. I would really like to try cold plasma, and the skin and body supplements, or any other product you think would be appropriate. If they work half as well as stated, they would be the answer to my fondest wish and in return I would become a walking, talking, texting, blogging advertisement for you and a faithful customer.

  50. recently aqired a feral colony reqiring lots of time and ex money could use a little help would love to test products keep me mind please thanks peggie 52

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