Perricone MD – Acyl Glutathione

The Crease Cure with concentrates on the accelerated signs of aging, including deep lines and wrinkles, severe dryness, extreme loss of elasticity, and fragile, thin skin.

This product helps create visibly enhanced skin in a mere 30 days and can be used as both a corrective and preventative moisturizer.

Find out more about Acyl-Glutathione :

  • Features and Benefits
  • Application and Ingredients
  • Recent Reviews

Features and Benefits of Acyl Glutathione

This patent-pending molecule, Acyl-Glutathione replenishes glutathione levels that rapidly depletes with age, stress, the environment, and less than optimal health. Glutathione replenishes skin and is critical to help skin’s defense against accelerated aging.


  • Hydrates skin and decreases deep wrinkles
  • Re-contours skin beginning to lose elasticity
  • Enhances strength of other antioxidant therapies
    • Patent-pending molecule.
    • Created to replenish glutathione, an antioxidant.
    • Works to fix those deficits and defy aging.

    Application and Ingredients of Acyl- Glutathione


    1. Apply a dime-sized amount of moisturizer to face.
    2. Gently massage onto skin

    Use in the morning and in the evening.


    Aqua (Water), Isopropyl Palmitate, Tetrahexyldecyl Ascorbate, Cetearyl Alcohol, Phosphatidylcholine, S-Palmitoylglutathione, L-Tyrosine, Dimethyl MEA (DMAE), Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Glycolic Acid, Oligopeptide-17, Oligopeptide-49, Squalane, Butyrospermum Parkii (Shea) Butter, Limnanthes Alba (Meadowfoam) Seed Oil, Docosahexaenoic Acid, Dimethicone, Sesamum Indicum (Sesame) Seed Oil, Glycerin, Magnesium Aspartate, Zinc Gluconate, Phenoxyethanol, Caprylyl Glycol, Parfum (Fragrance), Propylene Glycol, Disodium EDTA, Hydrolyzed Glycosaminoglycans, Elaeis Guineensis (Palm) Oil, Citric Acid, Tocotrienols, Copper Gluconate, Sorbic Acid, Tocopherol, Ascorbyl Palmitate, Thioctic Acid (Alpha-Lipoic Acid), Linalool.


    This product definitely works for me. I wanted to wait until I used it a fair amount of time before reviewing because I don’t want to mislead anyone, especially at this price point. I have seen improvement in fine lines and moisturization as well as firmness during the past three months of daily use. – From

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8 Comments • Please comment below


  1. I would like to know what if any Perricone eye product gets rid of milia? I’ve read about eye creams being to heavy and that causes this, I use the Philosophy line as a rule. I was told by an aesthetician that they need to be poked with a needle to remove them,needless to say I woke up the next day with 2 black eyes! I’m the mom of 7 and money is a issue for me to splurge on yet another hope of ridding this. Any advice would be greatly appreciate!

  2. Trying this product out to ensure I do not have any reaction. I like what I see so far (smooth, fine lines not as visible)Before I can give my review,I’d like to see the results with longer use.

  3. I’m 68 years old & have used your products for many years. People always tell me I have beautiful skin. I’d love to become a tester.

  4. I’m 68 years old & have used your products. People always tell me I have beautiful skin. I’d love to become a tester.

  5. I love the Acyl Gluthione Eye Cream and will forever buy this product. This was my first Perricone product and I am now interested in switching my skin care and want to try Cold Plasma next. Hopefully I will get to a store which can give me a sample in the next month or so as it is not sold in our town and I am really excited to see if it works as well as the eye cream!

  6. I was just given a sample of this product from Sephora to try for a couple of days around my eye area. I cannot wait to see if it helps my under eye wrinkles appear less obvious. I’d LOVE to be a tester for this product and for the Cold Plasma!I was told that the Cold Plasma should be used under this as it helps “jump start” or aid in the skin accepting and using whatever is put over it to a better advantage. Please consider adding me as a tester of your products. Thank you!

  7. I just used the acyl-glutathione on my orbital area last night for the first time. I woke up this morning with a red rash all over my face, neck and body. My lips look as though I’ve had injectibles. I’ve never had an allergic reaction to anything, and I’m 34. What could this be?!?!

  8. Hit 40 and creases under eyes make me look older. Would love a sample of these product. Saw ad in Marie Clare.