Neuropeptides: Messengers that Rejuvenate Skin

Among the specialized ingredients included in Dr. Perricone’s skin care collection, one in particular plays a key role in skin renewal. Neuropeptides work to energize and tone for face firming effects and to regain a vibrant texture and glow.

The neuropeptides in Perricone products provide patented, anti-aging technology combined with potent, yet non-invasive active ingredients to deliver visible results. They work synergistically to enhance the health and beauty of skin.

This article will discuss:

To understand neuropeptides, it is important to first distinguish them from peptides, a close relative. A peptide is a compound that possesses at least two amino acids that are linked by a peptide bond, which is a link that forms when two molecules undergo a chemical reaction.

Watch this video for a look at Dr. Perricone’s neuropeptide cream products:

Meanwhile, neuropeptides are a specific kind of complex peptide containing up to 30 or 40 different amino acids. Neuropeptides are found throughout the central and peripheral nervous systems. In terms of inflammation, neuropeptides can be either pro-inflammatory or anti-inflammatory; skin care experts obviously prefer the latter for their products.

The “neuro” in neuropeptides is a helpful clue as to the function of type of this particular peptide. Neuropeptides act as either hormones or as neurotransmitters (NTs). Neurotransmitters are small molecules that send signals from neurons to other cells located across the synapses, or junctions, between the cells. Essentially, neuropeptides are like tiny information superhighways for the cells in your body. Serotonin and dopamine are two of the most familiar NTs.

Neuropeptides are responsible for a number of physical and emotional processes. They control pain, pleasure, mood, body weight, provide energy, form memories, aid in regulation of the immune system, and allow for the ability to solve problems. But more important to the study of aging, these messengers serve as an activation point for cellular function in skin.

Researchers are so interested in neuropeptides because, more than any other NT, they transmit signals omnidirectionally. They can even direct transmissions in reverse. As neuromodulators, they can activate and deactivate other neurotransmitters.

One specific function of neuropeptides is serving as sophisticated intercellular messengers to deliver pheromones to the brain. The pheromones activate positive changes in the areas of the brain related to cognitive skills and emotional well-being. However, as we age, neuropeptides become less and less abundant. Dr. Perricone’s Synergy serum uses neuropeptides to harness the power of pheromones and enhance overall mental health and well-being.

Researchers have discovered a broad range of different neuropeptides that all have specific and vital functions within the brain and related neural network including:

  • Substance P – Transmits signals of pain from the peripheral to the central nervous system. Some researchers think it may also be involved in nerve regeneration.
  • Endorphins – An abbreviation of endogenous morphine, endorphins were discovered in 1975 by researchers John Hughes and Hans Kosterlitz. Endogenous means “produced naturally in the body.” Endorphins are neuropeptides in the central nervous system that act as painkillers by blocking the release of Substance P. They are associated with the “runner’s high.”
  • Methionine and l Eucine Enkephalins – Methionine and l Eucine Enkephalins – Neuropeptides that possess an extremely potent pain-relieving quality, even more than morphine. They also suppress the release of Substance P.
  • Beta-endorphins – The most euphoric of neuropeptides, composed of 31 amino acids.

These neuropeptides serve these basic purposes:

  1. Renew the surface of the dermis.
  2. Leave skin feeling more supple and toned.
  3. Improve skin resiliency.
  4. Smooth lines and wrinkles.
  5. Reduce the appearane of aging, sagging skin.

How do neuropeptides achieve these three things?

  1. Boost production of collagen and elastin.
  2. Quickly repair fresh wounds, and also older scars and wrinkles.
  3. Increase circulation which aids in the result of radiant skin.

Research into the power of neuropeptides to help rejuvenate skin continues today by Dr Perricone and others. Dr. Perricone believes his neuropeptide products can be a powerful tool to help give a fresh, youthful appearance to your skin and to boost your mental and physical health.


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14 Comments • Please comment below


  1. [...] Neuropeptides are small molecules that send signals from neurons to other cells located across the synapses, or junctions, between the cells. Essentially, they are tiny messengers for the cells in your body. [...]

  2. I would enjoy testing products. I am an honest person.

  3. [...] Contour and as indicated in its name, the active ingredients in this little miracle worker are neuropeptides. This product is supposed to aid in tightening the skin and reducing lines. I know a lot of women [...]

  4. Anxious to try this product!

  5. I am always impressed by how Dr. Perricone involves sound medical science into the development of his products. Love that!

  6. [...] firms skin and fights the appearance of wrinkles. Highly advanced conformer treatments with neuropeptides activate surface renewal to improve the look of even deep [...]

  7. Responsive to anything applied topically, my skin has recently been on a diet of products I make myself. Dr. Perricone’s research is fascinating and I would be interested in trying samples of his formulas and reviewing exactly the effect they had on my skin. For a sample of my writing see:

  8. Trillium, I’m pretty sure all of the neuropeptide products are now topical.

  9. I would welcome the chance to become a tester.

  10. I recently tried the Neuropeptidee Facial Cream and have been very pleased. I would like to sample more in this line, learn indepth the whole body approach for better skin and better health, and share my experiences online.

  11. I have long known that Dr. Perricone has scientifically developed the very best line of skin care products. I have a very low income so have not been able to purchase the products at Nordstroms and Sephora, but, have had some of their samples. I would like to write about the effacy of using the different products on my skin and face and report the findings on-line. Susan Clabault

  12. i’m seeking a product/regime for firming my skin.

  13. Perricone products are new to me, so I would welcome the opportunity to be a tester so as to determine which best meet my needs without the huge initial investment required by some of these products!

  14. “The Perricone Promise” 28-day program includes a “neuropeptide supplement,” but I can find no reference to them on this web site. Can you tell me what they refer to? Are all of the neuropeptide products now topical rather than ingested?