Face Cream Ingredients: What Works?

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Face creams serve various purposes, but not all are equally effective. To find the best products for your unique skin problems, check the label for powerful ingredients with specific processes that help skin.

Read on to learn why you should be looking for the following ingredients:


Dimethylaminoethanol (DMAE) provides both long-lasting and instant anti-aging benefits to your skin and body, even contributing to an “anti-aging face lift” in the right concentrations. DMAE occurs in the brain in small amounts to facilitate the synthesis of the neurotransmitter acetylcholine from choline and acetyl coenzyme A. Choline is critical for liver and muscle function, and acetyl coenzyme A interacts with other enzymes to build glucose and fatty acids.

Acetylcholine is essential to communication between nerves and muscles. For muscles to contract, acetylcholine must send the message from the nerves. Because of this, DMAE combats sagging that is associated with aging.

When applied to the skin in a cream or treatment, DMAE can help the skin to renew itself and maintain a healthy moisture balance. DMAE cream improves skin’s elasticity as the DMAE renews and restores skin cells. Because acetylcholine in involved with muscle activity, DMAE creams also help firm the skin by working to stimulate increased tone in the muscles behind the face.


Neuropeptides activate surface renewal of the dermis to deliver more toned, supple, and resilient skin. They are messengers in the brain that control cellular function; interactions between skin cells, skin immune components, and neuronal tissues occur through neuropeptides. Because of this, they can increase production of collagen and elastin, increase circulation, and repair scars and wrinkles.

Neuropeptides are small, protein-like molecules that neurons use to communicate with each other. When used in skin care products, these special molecules boost production of collagen and elastin and increase circulation.

Neuropeptides can have a number of positive effects on the skin including:

  • Surface renewal
  • More toned, supple, and resilient appearance
  • Lines and wrinkles smoothed
  • Diminished appearance of sagging skin


Phospholipids attract water from the air and hold water where hydration is needed. Damaging environmental factors such as sun, wind, and pollution can strip natural phospholipid content from the top layer of the skin. This loss results in rough skin and a pitted appearance. Moisturizing with products that contain phospholipids is a great way to replace this natural protective layer.


Polyphenols are antioxidants. Antioxidants fight premature signs of aging, enhance the immune system and aid in preventing health problems such as heart disease and cancer. They do this by protecting against free radicals, which are byproducts of the body’s oxygen use and other natural processes. They are unstable molecules seeking an extra electron to stabilize themselves. Free radicals seek these electrons from nearby molecules. This sets off a chain reaction as each successive, unstable molecule attempts to stabilize itself. The aftermath is misshapen and broken molecules that weaken cell structure and damage the body and skin.

Antioxidants protect cells by neutralizing both internal (e.g. stress and metabolism) and external (e.g. sun damage and pollution) forces that cause free radical damage. Polyphenols are an especially potent variety of plant-derived antioxidants with many potential health benefits resulting from their ability to fight free radicals.

The United States Department of Agriculture (USDA) has studied the link between antioxidant rich food and aging using a measurement called Oxygen Radical Absorbance Capacity. “Studies…suggest that consuming fruits and vegetables with a high-ORAC value may help slow the aging process in both body and brain,” says Ronald L. Prior, the USDA researcher.

Alpha Lipoic Acids

Alpha Lipoic Acid (ALA) is another powerful antioxidant. Every cell in the body contains ALA. It powers the body’s functions by converting glucose into energy, and also works as the ultimate antioxidant by neutralizing free radicals and combating aging.

One reason ALA is effective against aging is because it resists glycation. Glycation is the result of a sugar molecule bonding to a protein or lipid molecule without the controlling action of an enzyme. This process impairs the functioning of biomolecules.

As humans age, the number of glycated proteins in the body increases. It also protects proteins already exposed to oxidative stress, therefore reducing effect of aging on the skin.

Specifically, ALA works to:

  • Moderate the appearance of fine lines and wrinkles
  • Improve skin texture
  • Reduce pore size, puffiness, and discoloration

Perricone MD Face Cream

Dr. Perricone’s Concentrated Restorative Treatment is an excellent example of a face cream with powerful anti-aging ingredients that are the result of extensive research. A firming night renewal cream, it contains DMAE to tone and smooth lines and wrinkles.

Watch this video for more information about DMAE’s benefits:

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14 Comments • Please comment below


  1. I am 79 years old . most people are shocked, I look at lease 10 years younger. I HAD A GREAT FACE CREAM THAT I used only in the morning. They went out of business. I cant find any thing as good as it. It was a whipped and very light cream.Also I do not use any make up.

  2. I am 58 years old and have tried most creams to no avail, I am very interested to try any new products that may help

  3. Where do we get the product in Australia? SANDRA.

  4. [...] MD is said to have the best anti aging face cream and neck wrinkle cream. Here is your chance to win your very own Perricone MD product (up to $150 [...]

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  6. I would like to become a model for this product. I started taken care of my face when I was very young, due to being a model myself I had to look my very best. I’m now 40 years of age, and I’m on another mission for the best new age ingredients for women of my age. I will give my opinion about the ingredients of the product, and give a week to week photo up dates on the decrease affect on wrinkles and fine lines for women. Thank you for your time. Gina G.

  7. Please consider me to be a product tester.
    I am a 43 year old female.
    I spend a lot money trying products that
    I don’t feel they deliver on there promises. I do not mind spend money on a product I just want to know for myself they work. Thank you from a future costomer.
    Carol B.

  8. Hearing Dr. Perricone’s scientific effects of DMAE makes me feel better for people who are desperate in finding out the best skincare that fits them. Cheers to PerriconeMD Cosmeticeuticals!

  9. I would love to be a product tester for Perricone. I would welcome some help with my skin and the product sounds wonderful.
    Thank You

  10. lovely the whole Perricone line, the whole enchilada in a system that can transform troubled skin to beautiful skin. wonderfully perfect way to become a new better you…. I would love the opportunity to experience this remarkable skin care line as a product tester..

  11. [...] you know what face cream ingredients work? It is important to find ingredients that not only firm and lift, but add protection as [...]

  12. [...] choosing the right cleansers and moisturizers can go a long way in protecting your skin against winter wear and tear. Ingredients like [...]

  13. [...] Phospholipids (Phos E) work to: [...]

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