DMAE Cream to Lift and Firm Skin

DMAE, an abbreviation for dimethylaminoethanol, is a nonirritating antioxidant base that works to protect cells and rejuvenate skin, often in combination with amino acids and other nutrients.

Studies suggest that DMAE can play a role in making skin firmer, smoother, and brighter, while also reducing the appearance of lines and wrinkles. Dr. Perricone includes DMAE in 16 of his products, ranging from dietary dmae supplements and moisturizers to skin smoothers.

This article will discuss:

  • Effects of topical DMAE cream on skin
  • Who uses DMAE cream?

Effects of topical DMAE on skin

A multi-center, double-blind study designed to determine the safety of topical DMAE found that DMAE facilitated statistically significant improvements in the appearance of the skin. In this study, 156 participants at three different centers applied either a moisturizer containing DMAE or a DMAE-free placebo. Every 2 weeks, for an 18-week period, a dermatologist assessed the participants’ skin and rated improvement on a scale from 0 to 9.

In addition to showing virtually no irritation or dryness resulting from DMAE use, the study also produced proof of its efficacy as an anti-aging treatment. The dermatologists noted significant improvement in:

  • Overall appearance of aging skin
  • Forehead lines
  • Coarse wrinkles
  • Eye area
  • Lip area and smile lines
  • Sagging skin

Perricone MD also performed his own studies on the effects of topical DMAE on various parts of the body that could benefit from lifting and tightening, including the face (particularly the eye area, lips, and jawline), neck, thighs, and buttocks area. He found that treatments that include DMAE both work quickly and provide lasting results. Many people see visible effects within 30 minutes of using a DMAE treatment that last up to 24 hours, and repeated application of the treatment can help create permanent effects.


Dr. Perricone studied DMAE’s ability to increase skin firmness by applying DMAE lotion to one side of 17 participants’ faces and necks. After about 30 minutes, a dermatologist and a cosmetics expert judged the difference between the treated and untreated sides of the participants’ faces. They observed a visible improvement on the treated side that appeared to last 24 hours after just one application.

Once participants began using DMAE cream every day, they achieved even more dramatic results. DMAE promotes the production of acetylcholine, which is responsible for creating muscle tone and movement. Topical DMAE treatments can increase in muscle tone in the face to help create a lifted and more youthful appearance. Some of Dr. Perricone’s patients even reported that the tips of their noses appeared to lift, in response to a newly tightened forehead.

Neck and Jawline

DMAE cream has the same firming effects on the neck and jawline. With just one application, the skin tone of the neck improved. With several weeks of regular application, patients’ jawlines appeared more defined.


One of the most visible improvements that DMAE’s skin-tightening ability can bring about is an “eye lift” effect in creams and treatments targeted to that area.

Dr. Perricone’s eye lift cream combines DMAE with alpha lipoic acid and vitamin C ester to treat sagging and fine lines around the eyes and encourage a natural, visibly lifted look to the eyelids and surrounding skin.


DMAE, in combination with other antioxidants, can also produce a lip plumping effect. DMAE in products like Dr. Perricone’s Lip Plumper helps to increase circulation to the lips, making them look fuller and firmer.

DMAE can also address thin or lined skin around the lips.

Thighs and Buttocks

In stronger concentrations, DMAE may even address dimpling in the thighs and buttocks.

DMAE appears to produce visible improvement in about 20 minutes in those areas as well.

Dr. Perricone talks about his DMAE products in this video:

Who uses DMAE cream?

Dr. Perricone’s research has revealed that DMAE can produce beneficial effects on the skin of people as young as their twenties. DMAE can be a safe and effective treatment for any age and any condition of skin.

DMAE’s ability to help contour skin beginning to lose elasticity, capacity to tighten and tone, and power to help reduce the appearance of fine lines and wrinkles, make it a useful staple in the skin care routines of many types of people. Because of its nonirritating nature, it is even appropriate for sensitive or delicate skin.

As a cosmetic treatment to produce fast results or as a part of a broader anti-aging regimen, DMAE is a potent active ingredient that anyone interested in better skin can use and can be found in many of Dr. Perricone’s skin care products.

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165 Comments • Please comment below


  1. I am a 40 year old women and had a gastric bypass 2 years ago. I have a lot of loose skin that needs to be tightened up. I would love to become a tester for your product.

  2. I read that taking DMAE may be a problem ith breast cancer survivors. Is there any problem using it topically? If not I would like to become one of your testers.

  3. I have been trying for years to find a product that would non-surgically lift the skin around my eyes, forehead and mouth. I have not found anything that works. I would love to be a tester for DMAE.

  4. I am very interested in being a tester for you. I am 53 years old. And love to try a proven product. Thank You, Nancy

  5. I have read about you product, and would love to be a tester.

  6. I am 32 and just starting to watch in horror as my skin dulls, I develop dark spots and the skin around my eyes is puffing and wrinkling. Help! I would love to be a tester if it means keeping these wrinkles at bay!

  7. I have tried everything you can imagine and feel like I;m going broke trying them all and not one has worked for me. Please consider me as a tester!

  8. After being at home with my Mom this weekend I saw how much her skin has aged. The deep forehead lines and deep wrinkles over the lip area are a huge characterist in her side of the family….grandmother had deep forehead lines and my Mom’s sister does at age 60…I want to prevent this from happening to me as I age.
    I have very large pores and have tried about everything to help make them less noticeable. I would love to have the chance to try Dr. Perricone’s products and have a overall change in my skin’s appearance!
    I am 57 years old and have used Olay products for many many years…but having a chance to be a tester for your products would be fantastic for me and a great way to spread the word to other women about the wonderful products Dr. Perricone has to offer! If they see how much your products has made my skin brighter, also will give them the same confidence to want to use your products!
    I have lost weight and trying to improve my self image. I feel that it is time to make my skin a top priority..Please Dr. Perricone help me achieve that!
    Saw you on Dr. Oz and checked out DMAE!

  9. I would love to test this product. I have loose skin under my left eye that looks a bit strange and the right side of my face looks a lot smoother. This is rather embarrassing. I mentioned it to my doctor a long time ago but the NHS would not do an operation to correct I have to live with this ! I am hoping you will consider me as a tester even although I am a man. Men do want to try and look their best at any age.

  10. I am 65 years old. I can’t tell you the products I have tried and returned, because they don’ do what they say they will do. I am trying to find a product that will help my aging skin. I am on a fixed income and all of the good products that I read about I can not afford. I have read the comments. I would like tobecome a Perricone tester. Thank you.

  11. Hi! I’d love to become a tester! I’ve noticed wrinkling around my eyes & forehead lines that I’d like to reduce. I want to take preemptive steps to prevent jowls & reduce the appearance of cellulite on my thighs.

    This sounds amazing & I’d love to be an ambassador & document the journey!


  12. I would like to be a tester. I am 54 years old and have always had nice skin. I want to keep it this way. I purchased some DMAE cream and so far I like the quality and like the way it feels on my skin. It’s like a mini facial treat!

  13. I am 39 years old, a stay at home mom of 3 children. I still feel like I am in my 20′s and want to look on the outside like I feel on the inside, and I believe your products are the key. No time to start like the present. :)

  14. Hello doctor I have just turned 50 and am starting to see some shallow wrinkles and would like to stop or at least slow them from getting worse. I have been in the sun all my life working, playing sports and watersports. I think the sun is more damaging now than when I was younger. I stay out of the sun or use at lesst 55 sunscreen protection when outside. If you need help testing your product then I’m willing to help you tast and trust your judgement. Maybe it would help us both out. Thanks

  15. I am a 50 year old female who has lived in the florida sun all my life. I have tired all lots of items but nothing never works as good as you think they will. would love to be a perricon tester. would love to be able to buy a product that really does work. please consider me as a tester.
    Thank you…

  16. I am 53 years old and saw the Dr. Oz discussion about DMEA. While I try to take very good care of my skin I am looking for a product that can help improve the sagging and fine lines that I am starting to see. My other challenge is that unfortunately as a teen I was in the sun too much. So needless to say that wear and tear also shows on my face. Dr. Perricone I would appreciate any consideration you would offer me to be one of your testers.

  17. I am a 62 year old African American female. I have a fairly decent complexion. I change products a lot from Olay, Loreal and even paid $500 for the Estee Lauder lifting cream but did not see a difference in my complexion. I Keep searching for the perfect product which is probably why I change brands and products so often. BLUF: I’d love to be a tester. I work mostly with professional women and a few men so they can gauge the results.

  18. I saw Dr Perricone on a recent TV program and was so interested in the DMAE cream. I am turning 65 this month and I think I have aged well because I have always had a good skin routine, but I have noticed lines and some sagging around my mouth. I would love to be a tester for this product, I am not interested in a face lift so good products like this is what I am interested in. Thanks for your consideration.

  19. Saw Dr. Perricone on Dr. Oz and wandered if his products are as good as they are proclaimed to be?

  20. I am 39 years old about to be 40 in a couple of months. I have been using Olay products now for severals years without any success. What i’m noticing now is that i have sagging skin under my neck and jawline. Also i have dark circles around my eyes. I am now using Garnier products for firming the skin. It’s been about a month and i don’t see any visible changes. My husband told me about your product DMAE on Dr. Oz show. I actually google DMAE and got your website. I have read all the information that was provided for your product and think that this is a product that i would try. I mean what do i have to lose? I can only gain. Dr. Perricone, please consider me to be a tester for your product.

  21. I am a 62 year old male cancer survivor who has modified my diet, lost 30 lbs and would really like to be considered as a perricone tester. I saw your discussion of DMAE on Dr. Oz recently and figured my sun-exposed skin could be a real challenge but demonstrate dramatic results.

  22. My friend and I were in Sephora one day and my friend tried Dr. Perricone’s Lifting Serum and it worked!!! It was amazing within minutes the side of her face was tightened, she had to apply it to the other side to even out the effect. I am going to purchase the DMAE products for my face and neck. I am 62 years young, I have a good gene pool but with the stress of losing my job and being unemployed for over a year now has affected my appearance. I am tired of going on interviews and having them look at me as a old woman instead of an intelligent vibrant woman. It is true that appearance is a factor when applying for a job. I would very much like to be a tester for Dr. Perricone, I believe in his products and philosophy. Thank you very much for reading my email. Cannot wait to start using the DMAE products.

  23. Am 47.I saw Dr. Oz show on DMAE cream before and after and, I am highly impressed. Please consider me as one of your testers. I have a sensitive skin, and have tried many products, but non worked for me.

  24. I am 72 and had a face lift couple years ago. He didn’t do a very good job on the forehead and have creases on both sides. Some wrinkles along the cheeks and of course upper lip. I would love to be a tester for these products.

  25. I am a 56 year old dancer & instructor. In this day and age retirement is not an option for me for several years yet. I have been trying anti wrinkle products to help me keep a youthful look for as long as I can. Sadly, I’m not seeing any results. I’m concerned that if it is hard for me to look at myself in the mirror with my sagging jaw, lines around my eyes & mouth, forehead, then it must be hard for my audience and students to watch me. Dance is such a visual art form and I have a lot of dance in me to share. I am concerned that I will have to find another job just because of the look of my aging skin. Not an easy thing at my age. My hope is that testing your products would help give me back my confidence to continue sharing my passion with others.

  26. I just had eye lid surgery (blepharoplasty) at the age of 47. I’m really thrilled with the results but it makes me notice even more how my forehead and smile/mouth lines look awful. saw these products on the Dr. Oz show and it seems like the perfect product to compliment, without having further surgery. Please consider as a tester. Thanks!

  27. I recently went through chemo for colon cancer and it seems that I have aged ten years. I would love to test your Advanced
    Firming Activator. I am 66 years old, widowed last July and would just like to look a little better for however many years I may have left.

  28. I saw this on dr. oz and I want to try it as I am starting to look up in years and all my tennis friends are talking about different things like life lift and botox, but are afraid to try these. I am going to tell them about this next week when I see them at tennis

  29. I am 50 years old, sagging skin. Lots of acne since I was younger, dark scar and acne holes and blotches. I have aged considerably and I would like to be a Perricone tester. I have seen Dr. Oz show a couple days ago. I am interested in this DMAE products and would like to be a tester. Thanks you for your help.

  30. I am 65 years old and live in Florida. I do not lay in the sun though I did occasionally 25-30 years ago. I had a facelift at 55 and had my lower lids done 2 years ago. I feel as though I look my 65 years even though people tell me I don’t. My husband and I are both retired and on fixed incomes, I can’t afford to keep trying costly skin treatments. I have a cabinet full of creams that don’t work. I would love to be a Perricone tester. If the skin treatments prove to be as great as I heard when I saw him on Dr. Oz I would be thrilled to buy them. Please do consider using me as a tester.

  31. I saw this product on Dr. Oz show and would like to try it. I hate looking old but not being old in my spirit. I am 60 years old now and all of a sudden the downhill spiral of old age looking is rapidly getting out of control. Help!

  32. I saw you on Dr Oz show. I was looking to see products that have the dmae & came across this web site. I’m 55 with RA & osteoporosis for 10yrs plus & on lots of meds. They have made me age alot faster then I would like. So would love to be a tester for Perricone & have you recomend the produces I should use. I have deep line in my forehead, around my mouth (I never smoked),around my eyes, & sagging everywhere. I have tried inexpensive to expensive produces that didn’t work. I’m a salon owner would love my customer to tell me I’m looking like I feel better younger. If this would work for me I like to be your Perricone tester.

  33. The past two years I have lost my job(due to this economy)my sister died of a blood clot in her lung and my boyfriend called it quits. I’m also going thru perimenopause and have trigeminal neuralga. Now I look in the mirror and the sagging eyes and neck and the thin thin lips and winkles are just depressing. Please help. I have always tried to look my best but after this and taking to much meds for the pain I have also gained 20 lbs. I just need this to motivate me and get my self esteem back. help me please.

  34. I would consider being a tester for you. I’m almost 67 a can’t take estrogen due to having ovarian cancer 5 yrs ago. Always looking and trying out wrinkle and age prevention creams, etc. My face is sensitive to fragrances and creams so I use hypoallergenic creams. My neck is a lot worse that my face. But I need help for both areas. Do you think your products could help me. Daw Dr. Perricone on Dr. Oz. Thank You…..

  35. I am the most wrinkled part of old, historic Savannah, Ga. My circle of friends are searching constantly for a rejuvenation of their skin. Among the four friends and myself, we estimate to hav spent over 93,000.00 on plastic surgery. Please use me as a study case before I go to the poor house. I can tell my surgeon to take my number off his speed dial. Thanks and call soon.

  36. I was working out at the KROC center and watching TV and saw you. I’m interested in trying your products. I break out with some products so I use a lot of dermotologisted tested lotions fragrance free). I’m close to 67, survived ovarian cancer now 5 yrs. and cannot take estrogen. So my skin is showing problems and sometimes pre-cancers that need to be removed from my face and neck. Do you think you could help me?

  37. I am 61 and would like to become a Perricone tester! I’m retired with little stress. I’m very interested in trying DMAE cream for the lines around my mouth. I’m thin framed but these lines come from my family history. Please consider me.

  38. I’m a fan of the Dr. Oz show, I learn much there. The facial products I’ve used in the past year just don’t deliver! I research and seek out answers. The stress of the past 3 years has done something to my face I can’t describe! The economy has caused terrrble stress, and I also have RA, and our medical insurance is costly since my husband lost his job, and we pay COBRA. I know I would feel much better if I could take the stress effects off my face. It’s difficult, at 59 to look in the mirror and not see the same person I saw in 2008!Having always been called beautiful, it’s difficult to not see it in myself in such a short time-period. I would be very grateful to be a tester and hopefully regain the confidence I once had.
    I avoid the sun, and it is a harsh climate in New Mexico. When I became ill with the RA, I lost a lot of weight, and that hasn’t helped either. Thank you.

  39. I just saw Dr. Perricone on the Dr. Oz show. He recommended using DMAE for sagging skin. I’m 47 years old and the sagging has begun! My sister has been using Perricone products since I can remember. She’s 55 and has no sagging whatsoever. I’m ready to try the DMAE cream.

  40. I would like to be a tester of your products. I love taking natural things and I don’t use medicines at all with chemicals. I saw you on the Dr. Oz show. I am willing to come where ever you are.

  41. Hi,My name is deana and two years ago I married the best man in the whole world,I have to tell you that Im 15 years older then him.I feel like my wrinkles are starting to bather him.He stares at me,I know that he loves me but he would never say anything to hurt my feelings.Please help me look younger and feel better about myself.

  42. I am 66 years old but do not want to look like it. I eat well and exercise regularly, but need help with my wrinkles and face texture and brightness. Please help.

  43. I saw you on the Dr Oz show.I’ve wasted money on products that didn’t work.I’m very self conscious about wrinkles around my mouth, and would like to have a trail size of your product to try. Iuch have never smoked and look like a smoker. I have aged really bad due to so much stress in my life. My first child died in my arms when I was only 25 and the last 6 years I’ve struggled with my son being on drugs.Please conscider me as a tester.

  44. I am 34 and have not taken care of my skin as wel as I should have. I have used Clinique for years and have seen no improvement in my face. there are large pores, brown areas, wrinkles and my skin is dull and dry. I have ordered the DMAE set and have started using it. i would love to try other products before purchasing them due to teh expense.. please consider me for a tester..

  45. Every once in a while I’m able to buy say, one Perricone product and I really end up liking it. I’m unable to afford multiple products at this time, but have been dying to see how they work together. I am a former smoker/drinker who is now sober and just turned 41! Would love to turn over a new leaf with my skin. People tell me I look young, but I see things starting to happen: wrinkling, thinning, and perhaps the most disturbing development, a hint of sagging!! Being chosen for a product tester would actually be a fantasy come true for this fan!

  46. I would really like to try it, cause I heard it is very natural, I try to use the most natural products out there and I started getting wrinkles just now at 34years old, im too young to get wrinkles. I saw a womans results, but am iffy about what results I will get. I’m too scared to try anything cause i have such sensitive skin.
    thank you for the opportunity.

  47. I am 45 years old, and have severe orange peeled, dimpled tighs and buttocks for many years. I need a tremendous help to gain toness on my legs to diminish the appearance of cellulites. Please help me.

    Thank you.

  48. I,too saw the Dr. Oz show. I was so impressed I saw a night cream at VitaminWorld in Clovis, Ca. that contained DMAE…I have been using it nightly for 4 weeks and I have seen a nice difference, especially around my eyes. I am 50 yrs old and have been an Esthetician for 9 yrs. The product is by Reviva and contains Alpha Lipoic Acid, Vitamin C Ester, and DMAE. I have to use it to TALK it..Yay!

  49. I have seen Perricone products before in the store, however am unable to buy to test the product to see if it would work for me. I would definitely enjoy and be honored to become a tester for Perricone products.

  50. My friend uses dmae by dr perricone. Her skin wasn’t firm but after using the dmae by dr perricone , her skin look farm and lifted. She looks 10. Years younger than her age. I will like to try a sample if it dose the same for me