DMAE Cream to Lift and Firm Skin

DMAE, an abbreviation for dimethylaminoethanol, is a nonirritating antioxidant base that works to protect cells and rejuvenate skin, often in combination with amino acids and other nutrients.

Studies suggest that DMAE can play a role in making skin firmer, smoother, and brighter, while also reducing the appearance of lines and wrinkles. Dr. Perricone includes DMAE in 16 of his products, ranging from dietary dmae supplements and moisturizers to skin smoothers.

This article will discuss:

  • Effects of topical DMAE cream on skin
  • Who uses DMAE cream?

Effects of topical DMAE on skin

A multi-center, double-blind study designed to determine the safety of topical DMAE found that DMAE facilitated statistically significant improvements in the appearance of the skin. In this study, 156 participants at three different centers applied either a moisturizer containing DMAE or a DMAE-free placebo. Every 2 weeks, for an 18-week period, a dermatologist assessed the participants’ skin and rated improvement on a scale from 0 to 9.

In addition to showing virtually no irritation or dryness resulting from DMAE use, the study also produced proof of its efficacy as an anti-aging treatment. The dermatologists noted significant improvement in:

  • Overall appearance of aging skin
  • Forehead lines
  • Coarse wrinkles
  • Eye area
  • Lip area and smile lines
  • Sagging skin

Perricone MD also performed his own studies on the effects of topical DMAE on various parts of the body that could benefit from lifting and tightening, including the face (particularly the eye area, lips, and jawline), neck, thighs, and buttocks area. He found that treatments that include DMAE both work quickly and provide lasting results. Many people see visible effects within 30 minutes of using a DMAE treatment that last up to 24 hours, and repeated application of the treatment can help create permanent effects.


Dr. Perricone studied DMAE’s ability to increase skin firmness by applying DMAE lotion to one side of 17 participants’ faces and necks. After about 30 minutes, a dermatologist and a cosmetics expert judged the difference between the treated and untreated sides of the participants’ faces. They observed a visible improvement on the treated side that appeared to last 24 hours after just one application.

Once participants began using DMAE cream every day, they achieved even more dramatic results. DMAE promotes the production of acetylcholine, which is responsible for creating muscle tone and movement. Topical DMAE treatments can increase in muscle tone in the face to help create a lifted and more youthful appearance. Some of Dr. Perricone’s patients even reported that the tips of their noses appeared to lift, in response to a newly tightened forehead.

Neck and Jawline

DMAE cream has the same firming effects on the neck and jawline. With just one application, the skin tone of the neck improved. With several weeks of regular application, patients’ jawlines appeared more defined.


One of the most visible improvements that DMAE’s skin-tightening ability can bring about is an “eye lift” effect in creams and treatments targeted to that area.

Dr. Perricone’s eye lift cream combines DMAE with alpha lipoic acid and vitamin C ester to treat sagging and fine lines around the eyes and encourage a natural, visibly lifted look to the eyelids and surrounding skin.


DMAE, in combination with other antioxidants, can also produce a lip plumping effect. DMAE in products like Dr. Perricone’s Lip Plumper helps to increase circulation to the lips, making them look fuller and firmer.

DMAE can also address thin or lined skin around the lips.

Thighs and Buttocks

In stronger concentrations, DMAE may even address dimpling in the thighs and buttocks.

DMAE appears to produce visible improvement in about 20 minutes in those areas as well.

Dr. Perricone talks about his DMAE products in this video:

Who uses DMAE cream?

Dr. Perricone’s research has revealed that DMAE can produce beneficial effects on the skin of people as young as their twenties. DMAE can be a safe and effective treatment for any age and any condition of skin.

DMAE’s ability to help contour skin beginning to lose elasticity, capacity to tighten and tone, and power to help reduce the appearance of fine lines and wrinkles, make it a useful staple in the skin care routines of many types of people. Because of its nonirritating nature, it is even appropriate for sensitive or delicate skin.

As a cosmetic treatment to produce fast results or as a part of a broader anti-aging regimen, DMAE is a potent active ingredient that anyone interested in better skin can use and can be found in many of Dr. Perricone’s skin care products.

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165 Comments • Please comment below


  1. All my life I always looked years younger, I had beautiful clear skin. Once I hit 50 its been down hill for me. I’m 52 and would love to be one of your Perricone Testers.
    Thank you

  2. I am going to be 62 in June. I have been on the anti-inflammatory diet for 2 weeks. I have been receiving lots of comments about how wonderful my skin looks. I would love to be a tester so that I could try the products containing DMAE that were featured on the Dr. Oz show. Thank you!

  3. I am a 56 year old woman who as dark circles around my eyes and deep forehead crease and slight crows feet around the eyes.

  4. I too saw you on the Dr. Oz show…I am 43 years old and am very much interested, in becoming a tester…. I have tried numerous products to help fight the sagging Turkey neck, deep forehead wrinkles, and wonderful pouches of cellulite and dimples that seem to be finding comfort and homage in various areas across my body… I personally didn’t invite these happenings, but apparently aging has a mind of its own. Needless to say, I haven’t been able to find a product that matches up to promises they project.. i am hoping your product would actually be one that would change that disappointment. I will be attending both of my sisters weddings this summer and seeing people I haven’t seen in years…I wish I could look like those years haven’t passed! Could you please help!!!! Thank you for any suggestions!

  5. I saw you and your DMAE products on the Dr Oz show. I was interested enough to look for you and your products on the internet for more information. I was initially pleased to find that I could get a free sample of Cold Plasma with a small shipping and handling fee, than I was immediately very disappointed to find that there were no samples to be had. I wanted very much to try your cold plasma. I am interested in being a tester and would appreciate the opportunity. Thank you in advance for your consideration.

  6. I am 41 years old and am noticing sagging around my eyes as well as my jawline. Losing 40 pounds seemed to accelerate the aging process in my skin! Now that my body looks and feels better, I want my face to match!

  7. I am 68 years old and go to my dermatogist twice a year. I garden and play golf so I am in the sun but I do wear sunscreen religiously every day. I would like to be a test product tester as my skin now is showing sagging around my cheek and mouth.

  8. I am 56 years old and have a collection of skin products on my vanity and have spent a lot of money to try to find the one that would make my skin shine, I have sun damage, wrinkles around the eyes and sagging of the skin and chin, I lost my husband 3 months ago and somewhere down the road may ant to start dating again but would like to look and feel younger than what my face shows. I would be ever so grateful to begin a new regimen for my skin a be a product tester. I have done research and Dr. Perricone’s products are definitely the best and am axious to try DMAE along with other serums.

  9. I am 67 yrs old and had a facelift 5yrs ago. I have tried many creams and would like to be a tester for DMAE, as I am already showing signs of aging again.

  10. I am 62 and my skin has taken a dramatic downturn in the last yr. or so. Have been doing photo rejuvenation for 5 yrs. but it doesn’t seem to help any more, my skin is still wrinkling deeply, sagging, spotting and the pores seem bigger. I would love to be a tester for Dr. P’s products. PLEASE help me!

  11. User of obagi system but feel it is very stripping and makes your skin look lusterless and white from bleaching. Looking for zn alternative that really promotes good firming, resiliency !
    Dmae may be the new choice for me!

  12. I am 50 years old and am worried about the dark circles around my eyes and the frown lines between my eyes. I have tried other products but they’re all short lived and expensive. I have lines ony forehead and around the mouth, but I’m mostly concerned abouty face sagging. I would live to try Dr perricones products after watching him on Dr. Oz today.

  13. I am 48 years old and suffer from forehead wrinkles. I watched Dr. Oz talking about the DMAE cream. Trying to find a good one to use. Please help! I have read nothing but excellent reviews for Dr. Perricone products. I am absolutely willing to be a product tester. Thank you.

  14. I am about to turn 64 and most people say that I don’t look it. (I certainly don’t feel like it.) I exercise and eat right (most of the time)and I try to take care of my skin. But since I have been out of work since July I am having a hard time even buying the basic stuff. I would love to be a tester. I would not sabotage the regimen with bad habits.

  15. I am 61 and still break out. The dermatologist said I have rosacea and gave me a prescription for Metro gel. EXPENSIVE and not so sure it has improved anything. I have large pores and acne scarring. I have tried fillers and am somewhat happy. The texture of my face and neck make me not want to look in the mirror. I’ve tried lots of products but still the same old same old. I would love to try Dr. P’s products because I’m tired of trying stuff that doesn’t work. Please consider me as a tester because if it works for me it will work for everybody!

  16. I am 50 years old, saw your show with Dr. Oz. I would love to try the DMAE products, but I am unsure what to start with. I would like to try the one you discussed that was an anti-inflammatory and would see results in 20 minutes. I would love to be a tester for Dr. Perricone products.

  17. I saw this on Dr Oz yesterday. I would love to try it on the neck, eye, and lip areas. It’s hard to tell what really works, but the before and after photos on the show convinced me.

  18. I saw Dr Perricone on Dr Oz and felt confident that such a well respected physician would do his homework on a product he was allowing to be discussed on his show. There are a million products out there (I feel like I have tried most of them!)with minimal results and at great expense. I am not interested in surgical and unnatural looking (fillers) procedures. Even though I am 65, I have minimal damage from the sun that needs some tweaking. I would love to be a tester.

  19. I saw Dr. Perricone on Dr.oz show and would love to try some of his products. I’m 66 years old,but feel young. I have worked in scouts.I have sagging in my neck and would love to be consider being a Perricone tester. Have a Bless day

  20. I am 50. Although I eat relatively healthy and exersize I feel discouraged that my skin has become very dry over the last year and is rapidly aging. I dont buy the expensive products anymore because I have never found anything that works. A lot of the products are drying and never feel good on my face. I would like to try a product that does what it says it will do. A product that will make a difference in the way my face looks and feels.

  21. I am 70yrs I work 7days a week 10hrs a day. I try to look good for myself and
    the public. I would like to become a tester
    for perricone.I would like something for
    my face.

  22. I saw Dr.Perricone on the Dr.Oz TV show today and am very interested in the DMAE cream he spoke about. I am in my late fifties, worked hard to lose 73 pounds, have sensitive skin, and would like to improve my wrinkles and tone my sagging skin. I have tried other products with little improvement. I am active and fit, young at heart and thought, and would be a great candidate to be a tester. Being a teacher, I try to promote a positive attitude to my students, but sometimes they think I am frowning, due to my wrinkles. I would appreciate being considered to be a Perricone product tester. Thank you for your time and consideration. Cindi Blackman

  23. I had surgery several years ago where the doctor went through the front of my neck. Not only did it result in a keloid, but my neck area sags a whole lot. Since I am 58, I’m sure a lot of it also comes with age. Please consider me as a Perricone tester.

  24. I am 56 & would like to tighten my skin. I have had injections at the dermatologist & would love to try something less expensive. Please consider me as a product tester.

  25. I have used Obagi for many years, then decided it wasn’t doing much. So now I have enough creams and serums to fill a few grocery carts!I just read about DMAE and will definitly try it.I do believe that Dr. Perricone’s products are some of the best. Please consider me as a product tester. I NEED HELP!! Thank you, Donna Stevens

  26. I am a 62 year old woman, I seemed to be doing great but just this passed year I can see a vast difference, a lot more wrinkles around my eyes and the worst……… the deep lines above and around my lips, I truly hate these, I have tried numerous creams and potions but as yet have not found anything that is beneficial, I would so love to try your products, thus think I would make a great candidate for a Perricone Tester.

  27. I am 63 yrs old. My youngest son is getting married on March 12,2011. I feel like my skin really ages me. I have had a lot of health issues since Jan, and I think it shows in my face. I want to look my best, for the wedding, but I need help. I was a nurse for 30 years, but had to retire due to both knees needing a total knee replacement. I had gallbladder surgery in Jan. Can you help me? Thank you.

  28. I just watched Dr. Perricone on Dr. Oz and I would like to try the DMAE cream. It’s been almost 3 years since I’ve had a consistence sleep ever since my son was born and it has shown on my face, especially around my eyes. I would love to try this product and perhaps boost my confident which is lost long ago along with my youthfulness.

  29. Just read about your product and would love to be able to test it. I’m just starting to get wrinkles and would love to stop them in there tracks.


  31. want to be a tester


  33. Need it for the face, neck and jawline–lots of loose skin and sagging

  34. Thank you for considering my submission to become a product tester for Dr. Perricone’s products.

  35. I’m 62 years old. I’m physically active. Upon reviewing some recent pictures of myself, I was very upset to see the sagging of my jaw line and neck. I never know that I looked so old. I’ve read some great reviews about Dr. Perricone’s products and was wondering if a product that contains DMEA would really address my problem. I would love to become a product tester.
    Thank You

  36. I am 60 years old. My skin is starting to sag around the mouth…the creases on either side of the mouth.

    I saw the cream on Dr. Oz…it appears that this would help a great deal and saves me from getting a face lift

  37. I am 68 years young,I have some wrinkles on my cheeks and saging jaw,I can’t afford surgery,or other procedures so I would realy like to try this product.

  38. I am a 54-year-old with freckles over all parts of my body exposed to the sun. I would love to become a product tester to see if I can reduce these freckles and to address the sagging skin that has begun.

  39. Hi, ok just watch Dr. Oz. I am 45 years old and I am really starting to try to protect my skin and make it look better. I am heading out for watercress this afternoon. I am eating loads of fish, and vegies! Thanks so much.

  40. im 56 years old i have used many creams that say they get rid of fine lines and wrinkles but they do not! i really do not have a lot of wrinkles but however i am 56 and showing signs of aging. i would like to try your DMAE creme and wondering if that is all i need to tighten,firm and lift? i read your article on dmae and watched the larry king interview sounds great will have to try it.

  41. I am a 37 year old mother of 2, employed full time, and attend online classes full time. In my late twenties, early thirties I modeled and looked like I was 20 years old.

    I’m not certain if it is the stress of carrying such a full load, but it seems within the last year, the underneath part of my eyes has become dry with several fine lines. I am so self conscious that I have literally spent thousands of dollars on over the counter products. Even products such as Exuviance, Prevage, TNS and the finer lines. Nothing has worked. I am seriously considering botox. If I’m not even forty and already look like this, I can only imagine how horrible I’ll look in another 3 years. Please help. I would love to be a tester for your eye care products. The rest of my face looks youthful… just the eyes have aged, which my mother says are “the windows to the soul”.

  42. I have been using so many products for my face and the latest one is OLAY product but it seems like I’m not satisfied with the result that I see. I’m 44 years old my face starts to sag especially my laugh line it seems that I look sad because of the shape of my mouth. Please consider me with your product tester.

  43. Is DMAE good for preventing wrinkles and sagging skin? I’m in my mid thirties and have started to see a few lines here and there. I’ve started taking a supplement to help counter the signs of aging. I’m interested in seeing how topical DMAE helps to combat this effort.

  44. I have been using obagi for over, and am thrilled with overall texture of my skin.However,it has not done anything about my sagging skin. I an 56 years old and would die to have a product that would address this. I have been researching such products, the thing that really stands out is DMAE. I have read nothing but excellent reviews for Dr. Perricone products. I am absolutely willing to be a product tester.

  45. Iam searching for a complete line of products to use for my not so young skin. I don’t know where to start because there are so many products out there that promise guaranteed results. I’m always searching the web for products but don’t know which ones to try. Please consider me as a tester for your product.

  46. I was so excited reading about this product.I am so ready to start a new skin regime venture and become a Perricone tester.

  47. [...] DMAE [...]

  48. I currently use the Advanced Firming Activator. I am 46 years old and have lost 60lbs through diet and exercise over the past 10 months. My skin on the other hand needs all the help it can get. It lacks tone and firmness. And the wrinkles around my eyes got worse with every pound I lost. And my neck, it’s hard for me to even look at.

  49. I bought the Wrinkle Cure kit to try Dr. Perricone’s products for the first time. I really like the Advanced Face Firming Activator and felt a difference almost immediately. I would like to try other products that would complement this one. I am almost 50 and have lines around the eyes and sagging in my face and neck. I don’t want to look old because I don’t FEEL old. I’m just not certain what to try next.

  50. Watched Dr. Perricone on PBS. I pulled up his name to see what I could find. I am 43 years old, have wrinkles around my eyes when I smile and have sun damage. I start my junior year in college at University of Florida in 3 weeks. Would love something that made me not look so ancient compared to all the 21 year old Nursing students.

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