DMAE: A Versatile Supplement With Powerful Effects

DMAE (dimethylaminoethanol) has powerful effects on not only the skin, but overall health. Outside of skin care products, DMAE has been studied in relation to its potential benefits in the brain, ranging from treating mental health disorders to simply enhancing brain function. DMAE’s properties enable it to benefit both the skin and the brain, making it an extremely effective supplement.

The key to DMAE’s effects lies in its ability to combine with and enhance other compounds.


  • Provides its own benefits to the skin and brain
  • Complements the effects of other nutrients and antioxidants
  • Protects the body by acting as an antioxidant

This article will discuss:

  • Where to find DMAE
  • What the DMAE supplement does
  • How to maximize the benefits of DMAE

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Where to find DMAE

DMAE is found naturally in fish, especially salmon. However, it’s hard to get all you need just from eating fish, which is why Dr. Perricone recommends a DMAE supplement. DMAE is useful both as an ingested nutritional supplement and as a topical application which directly benefits skin.

DMAE is found in products with a wide range of applications, including:

  • Moisturizer
  • Lip plumper
  • Face firming
  • Nutritional supplement
  • Skin smoother
  • Pigment correction
  • Eye therapy and “eye lift” effect
  • “Face lift” effect
  • Emollient
  • Acne medication

What the DMAE supplement does

In addition to it topical use, DMAE is commonly taken as a nutritional supplement. Dr. Perricone applies the term “nutraceutical” to this product, a combination of the words “nutrition” and “pharmaceutical.” Taken orally, a DMAE supplement can benefit both the skin and the mind.

For the skin:
DMAE reduces the appearance of fine lines and acts as a wrinkle cure since it fosters the production of acetylcholine, a chemical that creates muscle tone. More muscle tone beneath the face results in tighter, smoother skin. DMAE supplements increase the amount of acetylcholine the body produces. Extra acetylcholine is especially helpful when supplies of acetylcholine naturally diminish as the body ages.

In supplement form, DMAE boosts acetylcholine in the brain and then spreads the chemical throughout the body. Instead of having only a targeted effect like topical creams, DMAE supplements have a total body approach to tightening and toning skin.

For the mind:
Dr. Perricone cites DMAE supplements as having effects in the brain like:

  • Clearer thinking
  • Improved memory
  • Better problem-solving ability

DMAE’s ability to boost the production of the neurotransmtter acetylcholine is also at the root of these brain benefits. Acetylcholine was the first neurotransmitter to be discovered by scientists and is the most plentiful neurotransmitter in the peripheral nervous system.

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Research on Alzheimer’s disease has indicated that there is a depletion of acetylcholine in the brain of Alzheimer’s patients. This depletion is hypothesized to cause memory loss and impairmed brain function. This is why acetylcholine is thought to play an important role in learning, memory, and other cognitive functions that are impaired in Alzheimer’s disease.

Take DMAE supplements only as directed, since an overproduction of acetylcholine can cause an imbalance in the brain. As long you follow label instructions, DMAE rarely has side effects. Reported side effects are mild and include headaches and muscle tension.

How to maximize the benefits of a DMAE supplement

Taking DMAE as directed in supplement form or using it as a cream have noticeable positive effects on the skin, mind, and overall health. DMAE is a supplement that can be a part of any topical product, as it enhances the effects of the other key ingredients while adding its own benefits.

To learn more about DMAE, watch this video:

However, Perricone MD recommends more than just the use of products in order to reap the benefits of DMAE as a supplement.

Diet and exercise are a key component of any successful health regimen. This is why Dr. Perricone suggests four steps to healthier skin with DMAE:

  1. Diet: Eat fish, especially salmon, as it’s the only significant source of DMAE.
  2. Exercise: A long-term exercise routine will keep the muscles toned (amplifying the muscle toning effects of DMAE), as well as greatly benefit overall health.
  3. Supplement: Use a nutritional DMAE supplement (always following product instructions).
  4. Skin: Apply a topical DMAE lotion to the skin on the face and body.

Combining these 4 steps optimizes the effects of DMAE supplements while improving overall health with healthy diet and exercise.By taking steps to improve nutrition and exercise, your body’s health will begin to improve naturally. Supplements should be used just as their name indicates, to supplement healthy choices, not as a substitute. For an extra boost, using a DMAE supplement helps on the road to better health.

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61 Comments • Please comment below


  1. How much alpha lipoic acid and DMAE
    Is needed daily

  2. I suffer from acne most of life. I just recently got to know about dr. Perricone products and they seem very interesting and truthful . I have two of his books and I find lots of useful information. Thank you

  3. I can’t wait to see what this awesome product will do because by the looks of it it will be a great benefit to my neurological health!

  4. I recently read The Perricone Prescription, and I absolutely love your science and products, would love to share the wonderful effects of products with all the women pre-retirees and retirees I work with everyday!! At 51 years old, things are noticably changing every day, we joke and laugh about the same time, we are searching for remedies, lol

  5. I need help with weight loss and skin discoloration.

  6. Have bad prob with hyper pigmentation not improved by retin-a, hydro quinone 4%.

  7. I wold love to be a tester Please ad me to you list.

  8. Need your advise for general Health of skin care

  9. Would love to test your product. I’m a gym junkie and always looking for the best new products.

  10. Somebody also recommended taking Red Yeast Rice 1200mg twice a day for high blood pressure. Currently, I am taking DMAE 350mg twice a day. Would it be alright to take both DMAE and Red Yeast Rice?

  11. Dmae is great,I am a combat sport athlete and use it for working out and concentration:-) I experience imediate results in my performance while taking it.It seems to aid in my recovery time and I also seem not need as much sleep.