Lines & Wrinkles

Acyl-Glutathione Deep Crease Serum

Acyl-Glutathione Deep Crease Serum
Forget laugh lines for good with Acyl-Glutathione Deep Crease Serum. This new
treatment is specifically designed to target the appearance of expression lines and
creases. The affects are visible right after use, with shallower creases, smoother skin,
and an illuminating effect.
Results from consumer studies show that Dr Perricone’s Acyl-Glutathione Deep Crease
Serum makes skin looks more relaxed and youthful after use. Users also saw wrinkles,
crease, and lines diminished.


  • 88% agreed their skin looked more luminous.
  • 85% said their face took on a more relaxed appearance and had a more pleasant
    and youthful expression.
  • 80% saw a smoothing of facial lines and creases by daily repetitive movement and
    agreed their laughter lines looked more shallow.
  • 80% said their eye wrinkles and creases looked diminished and they saw fewer
    creases around their lips.

Acyl-Glutathione Deep Crease Serum contains Dr. Perricone’s patented technology Acyl-Glutathione, combined with
synergistic peptides to comprehensively target deep creases.


Recent reviews


“Just developed some deep creases this year . Due to my sensitive skin fillers were out
of the question . Lucky for me Dr. Perricone brought us this wonderful serum which
is working wonderfully so far. I’m using this along with the deep wrinkle serum for a
one two punch particularly on the marionette lines. Thank you Dr. P for coming to the

“Glutathione is known for being a melanin inhibitor.”

“Glutathione Is the most important molecule you need to stay healthy and prevent disease — yet you’ve probably never heard of it. It’s the secret to prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer’s disease. There are more than 89,000 medical articles about it — but your doctor doesn’t know how address the epidemic deficiency of this critical life-giving molecule .”

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Sampling program

Firming & Lifting set

It’s that time of the year again. The kids are off to school, leaves are changing, and another winter is not far away. Also like so many previous years, the changing of season brings changes to your skin. Because money can be tight at this time of year, starting a new regimen can be tough; Even if your skin is crying for treatment.

Luckily, Dr. Perricone has you covered with his sampling program. Save money and try some of the Drs’ most popular products without breaking the bank.

Wrinkles and Loss of Elasticity

Dr. Perricones Firming and Lifting set is a great way to start off if you need help with wrinkles and loss of elasticity. With the low price of $45 ($107 value) you can try 3 of his most powerful wrinkle fighters.

Start by removing impurities, makeup and pollution from your skin. The nutritive cleanser gently cleanses your skin and quickly removes these impurities. Follow that with the High Potency Face Lift to firm and lift your skin. And finally finish off with the High potency evening repair before heading to bed to make sure your face stays a supple and youthful complexion.


Pore Eraser Set

Depending on your skin type, your pores could have been a problem since you were a teenager. Sampling the Pore eraser set is an affordable and effective way to combat those pore problems. With three exclusive treatments included at only $49 ($109 value), it is easy to see why this set is a customer favorite.

Start first by flushing the skin and cleaning it with Perricones’ Nutritive Cleanser. Follow up by tightening those pores to keep the dirt out with the best-selling Advanced Face Firming Activator. End the treatment with Face Finishing Moisturizer. Essential to keep your skin moist while not clogging pores.

Wrinkles and Pores

Having trouble with both wrinkles and pores? The sampling program has you covered there too with the perricone 7-piece collection. For a mere $95 ($180 value), try all of the products in the wrinkle and pore refining kits. In addition, receive some extra treatments such as the Serum Prep and High Potency eye lift.

You can find all of these samples in our sample perricone section located at the top of the page. These samples change often. So hurry before these run out!

Formula 15

Formula 1515 years after his smash hit, Advanced face firming activator (AFFA), Dr. Perricone is at it again and brings you formula 15. Specially formulated with DMAE and Alpha Lipoic Acid, formula 15 is the AFFA of the future. A professional grade of AFFA, Formula 15 is a potent, powerful, and highly efficacious treatment.

Results from consumer testing show that Dr. Perricone’s Formula 15 provided an improvement in wrinkle length, width and depth.


  • 81% demonstrated a measured improvement in their wrinkle length
  • 68% demonstrated a measured improvement in their wrinkle width
  • 75% demonstrated a measured improvement in their wrinkle depth

Formula 15 soften and smoothes the skins’ texture upon application. While doing so, formula 15 restores the youthful glow and suppleness of skin.


The secret

The ingredients of Formula 15 are the key to its success. Formulated with Alpha lipoic acid (ALA), Formula 15 autoxidizes while diminishing wrinkles, discoloration, and fine lines. In addition, this powerful acid in Formula 15 also minimizes puffiness, uneven skin tone, imperfections and pore size.

As well as Alpha lipoic acid, Formula 15 also boasts Dimethylaminoethanol (DMAE) which fights the loss the elasticity common in aging skin. By doing so, DMAE lifts, tightens, and tones the appearance of skin while diminishing the appearance of facial and under eye wrinkles and fine lines.

Alpha Lipoic Acid – Its uses and side effects

Alpha lipoic acid, like vitamin C and E, is an antioxidant. However, unlike Vitamin C and E, Alpha lipoic acid is both water and fat soluble. Whereas Vitamin C is only water soluble and Vitamin E is only soluble in fat.

As an antioxidant, Alpha lipoic acid attacks what are called “free radicals” or left over waste from the body when glucose is transformed into energy. The waste left over from the transformation can damage cells through harmful chemical reactions. This damage can further strain the body when trying to fend off infections.

Alpha Lipoic Acid and the Skin

Lip Plumper

In addition to fighting off waste, Alpha lipoic acid is also an effective remedy for many skin conditions including removing wrinkles, reducing large pores, and even minimizing the appearance scars.

Dr. Perricone offers an entire line of topical skin care products with Alpha lipoic acid as a key ingredient that promise to reduce wrinkles and minimize pores. In addition, lists an alpha lipoic acid treatment which promises to better define and plump your lips.

Side effects

Alpha lipoic acid side effects vary from person to person. Current side effects known, for otherwise healthy adults, can include skin rash, cramping muscles, headache, stomach ache, tingling sensation (pins and needles), nausea, lowering of blood sugar, and lowering of thiamine.

The last two side effects are especially important for those with diabetes or those who drink alcohol regularly. Dr. Perricone recommends that you talk with your primary care physician before starting any supplement regimen.

Goodbye to Under Eye Wrinkles: Stay Looking Forever Young

High Potency Eye LiftThere are some definite perks and benefits to getting older; however, developing crinkles under your eyes is most certainly not among them.

Wrinkles under the eyes automatically age a person, causing them to look and even feel older. Knowing what causes wrinkles, tips to preventing wrinkles, and the products available to help reduce them can help you stay looking young and smooth.

In this article, learn about:

  • What causes under eye wrinkles
  • How to reduce under eye wrinkles

Read more »