Are There Any DMAE Side Effects?

DMAE is naturally produced in the body to maintain brain and body health, but taking too much DMAE in supplement form can cause side effects.

Taking more than the recommended amount can cause DMAE side effects like:

The healthy recommended dose of DMAE is between 100-300 mg. However people should start taking DMAE at the lowest dose directed, then increase the amount with time.

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People with schizophrenia, epilepsy, and manic depression should not take DMAE supplements. However, DMAE can help people with Attention Deficit Disorder, autism, memory deficiency, dementia, and depression. Increased doses of DMAE block the acetylcholine receptors, which allows more dopamine to be released.

DMAE supplements can help improve many brain functions and can even make skin healthier. DMAE can tighten and tone skin while reducing wrinkles, fine lines, and age spots. DMAE has also been linked to helping with weight loss.

DMAE has a number of benefits:

  • Increases memory, concentration, and cognitive learning
  • Improves alertness and energy
  • Decreases anxiety
  • Boosts dopamine effects
  • Contours, tightens, and tones skin
  • Reduces appearance of fine lines and wrinkles

Dr. Perricone has a line of supplements for beautiful skin, energy and mood, total health, and weight management.

His DMAE supplement is one of his total health supplements. This supplement provides a safe daily amount of DMAE.

One 75 mg pill (1 serving) should be taken twice a day with meals. Taking 2 pills a day is a healthy amount of DMAE to experience benefits without DMAE side effects.

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192 Comments • Please comment below




  2. I am 2 years shy of 60 and would value the opportunity to become a tester of your products.

  3. I’ve just started taking DMAE pills a week ago and not sure if any difference yet. From all I have read on it I feel it will be a boost to my system. My only concern is any side effects.

  4. After reading quite a bit, it seems that all negative side affects are related to taking more than the recommended amount. Taken properly, it sounds well worth a test. I’d like to minimize wrinkles on my face; and also, reverse the “brain fog” that sometimes crops up; as well as a slowing in memory and recall.

  5. I’ve been blessed with great skin but now that I’m on the shy side of 60, I could use some professional help. My primary issues involve (a)crows feet and (b)skin texture. I prefer to try natural measures, especially under your guidance.

  6. I have been taking DMAE supplents for two years now to help with ADHD. I was prescribed 40 milligrams of adderrall before I started taking the DMAE. The adderrall was very effective in treating ADHD, but after awhile the medication felt toxic and my anxiety levels rose. I decided to try DMAE instead of prescription medication and I am very pleased. My concentration levels have increased, and I am in a much better mood than I was on adderrall. There is no anxiety and I can go to sleep better at night. The adderrall made my skin oily and break out, but since taking the DMAE it is clear and beautiful. I am maintaining a healthy weight with DMAE as opposed to being underweight on adderrall. Overall I feel much healthier, happier, and smarter on DMAE!

  7. I’m 36 years old and I feel that I’m in my 50′s already by looking at my skin and my face, I already have really bad dark circle under my eyes, and some wrinkle all over my face. I think if I had the opportunity to become a tester for this product it will help people my age who feel the same way.

  8. I have used the 3 skin supplements for years (esterC, DMAE and alphalipoic acid), but recently i’ve run out of esterc and DMAE. I notice a double chin and even more annoying, circular growth on the right side of my neck in the double chin area… i’d be a little more concerned but i’ve noticed on others, include mick jagger from the grammys, BUT, I know how to get rid of it… will be getting my DMAE/EsterC soon. my chin line is much more defined when i use these products. would love to be a tester, but will probably be able to tell if i’m getting the placebo.

  9. I just started on the Perricone regime again after 5 years off. I started in my early 40s and am now 50 and am really starting to see facial sagging.

    I immediately noticed that after taking the DMAE I was not having the fatigue and fogginess issues I’ve been fighting for the past couple of years (perhaps from hormonal changes).

    My father (86) is having major short term memory issues, although long term memory is intact. He is also on high blood pressure medicine and statins. Would it be safe for him to try DMAE for memory or would it interfere with either his blood pressure or statin medications.

    Most doctors simply tell you not to take any supplements, so it’s hard to find out what is safe to take with prescriptions and what can cause problems.


  10. I’m 45 and have Rheumatoid arthritis, which is an inflammatory disease, and very much so in my case. I have a bit of ADHD and an aging, blemished face. I’m a bit over weight and my overall system could use some help. I hear that DMAE can help with sore joints, depression, adhd, wrinkles and memory. I would love to be a candidate to try Dr. Perricone’s Skin care products, as I also have a four year old and I’m often mistaken for Grandma, instead of Mom. I’m considering the oral supplement after viewing Dr. Oz’s show on which Dr. Perricone appeared.

  11. Hello from Texas. I will be 65 this year and although I don’t feel that I have a lot of wrinkles, I have little elasticity along the jaw line. I too have some memory issues but just attributed it to age. I do try to watch what I eat, I exercise, and do take some supplements. I would love to become a tester for Dr. Perricone.
    Thank You!

  12. I am 40 and have discovered that I have ADD plus after being given the painkiller Dilotid (sp) while I was in the emergency room about 4 years ago, I have noticed a huge difference (decline) in my memory – mainly short-term – but enough that it made me question it and discover the ADD!

    I also have general allover sagging starting- makes me look tired. I have wrinkles as well – fine lines around the eyes mostly. Considering my sun and saltwater exposure over the years, I have pretty good skin, but it could be better! I would love to be able to test out the DMAE products!

  13. My body and mind are a mess. I have tried so many different drugs and now I am trying to find more natural solutions. Unfortunately, due to financial issues, I have to do all on my own. So, I would appreciate being a Perricone Tester. Hopefully, I can find something to help me.

  14. I seen you on Dr. OZ and I would be interested in beging a Perricone tester.

  15. Hi..I am in my mid 50s..and I was recently watching the Dr Oz Show..and Dr Pereicone was on there..and they were talking about the benefits of DMAE for the skin!! i have always tried to use good skin care and take supplements..but have never tried DMAE!! I would Love to become a tester and see how it helps my skin!! Thank You!!

  16. I am 77 years young & have loved the sun all my life, now I need help to get my skin back to a healthy state!I have read about your DMAE cream/serum & would like to try it to see if my skin improves!
    How can I become a “Perricone Tester”?
    Your response will be appreciated!!
    Thank you !

  17. I am 50 and i would like be a tester, to help my memory.

  18. Hi, I would love to test DMAE in a topical and/or oral format. I am 46 and in good shape and eat well but still have loss of fullness in my face and wrinkles under my eyes. I just saw you on Dr. Oz and would love a chance to test this after your great words about it on the show and your wonderful work.
    thank you.

  19. I would like to become a tester. Off to purchase a few books.


  21. I would be interested in testing DMAE both for skin and cognitive function. I am early 60s.

  22. I am in my 60′s and have noticed wrinkles around my mouth which seem to be getting deeper. I have never smoked and would love to be able to test one of your products. I’ve tried several different products without results.

  23. I would love to be a Perricone tester especially after seeing Dr Perricone on the DR OZ show. I had not heard about this product and was very impressed with the information Dr Perricone presented. I am 65 years old with sagging skin (face & neck) and would also be interested in the memory and concentration results of DMAE. Please consider me! Thanks!

  24. I am very interested in becoming a tester, I was recently diagnosed hypothyroid and it shows in my skin and hair.

  25. I would like to see if DMAE helps depression. All the other benefits would be icing on the cake. Or watercress in the salad.

  26. I am 72 years old. My cheeks and eyes are begining to sag. I would like to fade the “witch’s” vertical lines above my lips.

    I would appreciate a chance to test a Perricone product. Thank you.

  27. I am 72 years old with basically “good” skin. However, lately it sags and I’d love to rid myself of the witch’s upper lip I’ve had for some time. My eyes could use help also. I am planning to lose a bit of weight and – without help – I fear that my face will really sag!

    I’d love to be a Perricone tester. A former “prom gueen,” I’m still vain after all these years.

  28. Trying to take care of myself. I am 65 years old and would love to be a tester.

  29. Am 63 yo, female. Need help! 45th high school reunion coming up! Have pretty good skin,not much sun damage, but skin is not firm, especially neck and eye area. Would love to become a tester.

  30. I have 6grandkids at the age of 47 . I am gradually seeing my skin sagging and just seen the dr oz show and they mentioned dmae is the best. Could I please be informed of what you are offering? Thank- you

  31. Saw u on Dr Oz this morning! Gotta get some of this!!!

  32. I am 64 years old.
    I have been using all kind of products to firm my skin and make my face smooth.
    My skin is great but I am loosing the contour of my face. From my chin to my ears the skin starts sagging.
    I don’t want to have a surgical face lift and I don’t want to take any internal medicine. Would any of your external products alleviate my problem?
    I would appreciate and value your honest answer.
    Thank you so much

  33. I will turn 50 this year. I don’t have a lot of wrinkles but would like to sustain a youthful healthly look of my skin. Also to help improve my memory. I saw you on Dr. Oz and do some of the other things you recommend for healthy skin. I would really like to give this a try as well.

  34. I really have nothing wrong with me. I would like to become a tester to help strengthen my memory.

  35. 55 y.o. I have been diagnosed with ADHD and I teach middle school special ed. emotionally disturbed and autistic students. STRESS! I’d love to be a tester.
    Willing to do the diet again as well because I LOVE salmon, although I have tried a vegan (Dr. McDougall) diet for about 3 weeks, my sugar cravings have gone and I feel calmer. I do notice my neck area losing firmness. I’m sure it’s because I am eating so many carbs.

    My sun damage has decreased over the years. I use Dr. Lancer products.

  36. Hello, I am 41 years old and have wrinkles under my eyes and loss of firmness on my face and some loss of memory too.I would really loved to try out DMAE. Thank you sandra

  37. I have tried many of your supplements and love them but the DMAE is causing me to have stomach cramps. Is that normal?

  38. 45 year-old with loss of skin suppleness and beginning to see wrinkles! Also newly diagnosed with ADHD. Would Love to be a tester please!.

  39. My son has Autism and is on a biomedical regiment and i would love to try DMAE on him to see if there areany changes. I also have sun damage on my face and and would love a chance to try out the new cream to see if it could help with the age spots. I would love to be a tester Melissa

  40. Hi I am 46 years old and have wrinkles under my eyes and some loss of firmness on my face. I would really appreciate the chance to try out DMAE. Thank you, Kathleen

  41. Been taking DMAE for 6 months now and have no lines or wrinkles. Even at 41 people mistake for between 25-28 all the time! They freak out when I tell them I have a 16 year old! I LOVE DMAE!!

  42. I would like to become a Perricone tester. I am 52. I have puffy eyes, with wrinkles under my eyes. Saggy cheeks and a little bit of a double chin.

  43. I am 22. I’ll give it a whirl!

  44. I am in my mid 50′s and have issues with memory, concentration, motivation, and also loss of skin tone, and I would love to become a tester to see if this product helps with any of these.

  45. I am in my 50′s and would love to test it for fine lines and protruding chin and forgetfulness!

  46. Hello,

    I am in my mid 60′s and have noticed a decrease in my memory capabilities. I would love to be a tester of this product to see if it will also help older adults.

  47. I have been reading Dr. Perricone’s book and would love to become a tester.

  48. i would like to become a tester.

  49. I would love to become a tester!!

  50. I started using DMAE in my facial lotion at night before bed. All I can say IT WORKS! I had sagging skin and I was getting a double chin I am 40 years old and I did not like what I was seeing. I have now been using it for about 4 months. You can tell definetly in pictures.